Contraindicated in:
Use Cautiously in:
CV: CARDIOMYOPATHY, ECG changes.
Derm: alopecia, photosensitivity.
Endo: sterility, prepubertal growth failure with temporary gonadal impairment (children only).
GI: diarrhea, esophagitis, nausea, stomatitis, vomiting.
GU: red urine.
Hemat: anemia, leukopenia, thrombocytopenia.
Local: phlebitis at IV site, tissue necrosis.
Metab: hyperuricemia.
Resp: recall pneumonitis.
Misc: hypersensitivity reactions.
Drug-Drug:
(Generic available)
Hepatic Impairment
Absorption: Administered IV only, resulting in complete bioavailability.
Distribution: Widely distributed; does not cross the blood-brain barrier; extensively bound to tissues.
Metabolism/Excretion: Mostly metabolized by the liver (primarily by CYP2D6 and CYP3A4). Converted by liver to an active compound. Excreted predominantly in the bile, 50% as unchanged drug. Less than 5% eliminated unchanged in the urine.
Half-life: 16.7 hr.