| alprazolam (Xanax) (Xanax XR) |
| amiodarone (avoid using as first-line therapy for atrial fibrillation unless heart failure or significant left ventricular hypertrophy present)(Pacerone) |
| amitriptyline |
| amobarbital (Amytal Sodium) |
| amoxapine |
| aripiprazole (avoid use, except in schizophrenia or bipolar disorder)(Abilify) (Abilify Maintena) |
| asenapine (avoid use, except in schizophrenia or bipolar disorder)(Saphris) |
| aspirin (avoid using dosage >325 mg/day) |
| atropine (does not apply to ophthalmic formulations)(Atropen) |
| belladonna alkaloids (Donnatal) |
| benztropine (oral only)(Cogentin) |
| brexpiprazole (avoid use, except in schizophrenia)(Rexulti) |
| brompheniramine |
| butabarbital (Butisol Sodium) |
| butalbital |
| carbinoxamine (Karbinal ER) |
| cariprazine (avoid use, except in schizophrenia or bipolar disorder)(Vraylar) |
| carisoprodol (Soma) |
| chlordiazepoxide (Librium) |
| chlordiazepoxide-amitriptyline |
| chlorpheniramine (Chlor-Trimeton) |
| chlorpromazine (avoid use, except in schizophrenia or bipolar disorder or for short-term use as antiemetic during chemotherapy) |
| chlorzoxazone |
| clemastine (Dayhist Allergy) |
| clidinium-chlordiazepoxide (Librax) |
| clomipramine (Anafranil) |
| clonazepam (Klonopin) |
| clonidine (avoid use for first-line treatment of hypertension)(Catapres) (Duraclon) (Kapvay) |
| clorazepate (Tranxene) |
| clozapine (avoid use, except in schizophrenia or bipolar disorder)(Clozaril) (Versacloz) |
| cyclobenzaprine (Amrix) (Fexmid) |
| cyproheptadine |
| desipramine (Norpramin) |
| desmopressin (avoid use for treatment of nocturia or nocturnal polyuria)(DDAVP) (Nocdurna) (Noctiva) (Stimate) |
| dessicated thyroid (Armour Thyroid) |
| dexbrompheniramine |
| dexchlorpheniramine |
| dexlansoprazole (avoid scheduled use for >8 wk unless for high-risk patients or patients with erosive esophagitis, Barrett esophagitis, or pathological hypersecretory condition)(Dexilant) |
| diazepam (Valium) |
| diclofenac (Cambia) (Zipsor) (Zorvolex) |
| dicyclomine (Bentyl) |
| diflunisal |
| digoxin (avoid using for first-line treatment of atrial fibrillation or heart failure; avoid using dosage >0.125 mg/day)(Lanoxin) |
| dimenhydrinate (Dramamine) |
| diphenhydramine (Benadryl) |
| dipyridamole (short-acting) |
| disopyramide (Norpace) (Norpace CR) |
| doxazosin (avoid using for treatment of hypertension)(Cardura) |
| doxepin (avoid using dosage >6 mg/day)(Silenor) |
| doxylamine |
| dronedarone (avoid use in permanent atrial fibrillation or in patients with severe or recently decompensated heart failure)(Multaq) |
| ergoloid mesylates |
| esomeprazole (avoid scheduled use for >8 wk unless for high-risk patients or patients with erosive esophagitis, Barrett esophagitis, or pathological hypersecretory condition)(Nexium) (Nexium 24HR) |
| estazolam |
| estrogens (with or without progestins) (avoid systemic estrogens; intravaginal formulations acceptable to use) |
| eszopiclone (Lunesta) |
| etodolac |
| fenoprofen (Nalfon) |
| fluphenazine (avoid use, except in schizophrenia) |
| flurazepam |
| glimepiride (Amaryl) |
| glyburide (Diabeta) (Glynase) |
| growth hormone (avoid unless used for confirmed growth hormone deficiency) |
| guanfacine (Intuniv) |
| haloperidol (avoid use, except in schizophrenia or bipolar disorder or for short-term use as antiemetic during chemotherapy)(Haldol) |
| hydroxyzine (Vistaril) |
| hyoscyamine (Anaspaz) (Levsin) |
| ibuprofen (Advil) (Motrin) |
| iloperidone (avoid use, except in schizophrenia)(Fanapt) |
| imipramine (Tofranil) |
| indomethacin (Indocin) (Tivorbex) |
| insulin (avoid use of regimens containing only short- or rapid-acting insulin without concurrent use of basal or long-acting insulin) |
| isoxsuprine |
| ketoprofen |
| ketorolac |
| lansoprazole (avoid scheduled use for >8 wk unless for high-risk patients or patients with erosive esophagitis, Barrett esophagitis, or pathological hypersecretory condition)(Prevacid) (Prevacid 24HR) (Prevacid SoluTab) |
| lorazepam (Ativan) |
| loxapine (avoid use, except in schizophrenia or bipolar disorder)(Adasuve) |
| lurasidone (avoid use, except in schizophrenia or bipolar disorder)(Latuda) |
| meclizine |
| meclofenamate |
| mefenamic acid (Ponstel) |
| megestrol (Megace ES) |
| meloxicam (Mobic) (Qmiiz ODT) (Vivlodex) |
| meperidine (Demerol) |
| meprobamate |
| metaxalone (Skelaxin) |
| methocarbamol (Robaxin) |
| methscopolamine |
| methyldopa |
| methyltestosterone (avoid unless used for confirmed hypogonadism)(Android) (Testred) |
| metoclopramide (avoid use, except in gastroparesis [use should generally not exceed 12 wk])(Reglan) |
| mineral oil (oral) |
| nabumetone |
| naproxen (Aleve) (Anaprox) (Naprelan) (Naprosyn) |
| nifedipine (immediate-release)(Procardia) |
| nitrofurantoin (avoid using if CCr <30 mL/min or for long-term suppression of urinary tract infections)(Furadantin) (Macrobid) (Microdantin) |
| nortriptyline (Pamelor) |
| olanzapine (avoid use, except in schizophrenia or bipolar disorder or for short-term use as antiemetic during chemotherapy)(Zyprexa) (Zyprexa Relprevv) (Zyprexa Zydis) |
| olanzapine-fluoxetine (avoid use, except in bipolar disorder)(Symbyax) |
| omeprazole (avoid scheduled use for >8 wk unless for high-risk patients or patients with erosive esophagitis, Barrett esophagitis, or pathological hypersecretory condition)(Prilosec) (Prilosec OTC) |
| orphenadrine |
| oxaprozin (Daypro) |
| oxazepam |
| paliperidone (avoid use, except in schizophrenia or bipolar disorder)(Invega) (Invega Sustenna) (Invega Trinza) |
| pantoprazole (avoid scheduled use for >8 wk unless for high-risk patients or patients with erosive esophagitis, Barrett esophagitis, or pathological hypersecretory condition)(Protonix) |
| paroxetine (Brisdelle) (Paxil) (Paxil CR) (Pexeva) |
| pentobarbital (Nembutal) |
| perphenazine (avoid use, except in schizophrenia or for short-term use as antiemetic during chemotherapy) |
| perphenazine-amitriptyline (avoid use, except in schizophrenia) |
| phenobarbital |
| pimozide |
| piroxicam (Feldene) |
| prazosin (avoid using for treatment of hypertension)(Minipress) |
| prochlorperazine (avoid use, except for short-term use as antiemetic during chemotherapy)(Compro) |
| promethazine |
| propantheline |
| protriptyline |
| pyrilamine |
| quazepam (Doral) |
| quetiapine (avoid use, except in schizophrenia or bipolar disorder)(Seroquel) (Seroquel XR) |
| rabeprazole (avoid scheduled use for >8 wk unless for high-risk patients or patients with erosive esophagitis, Barrett esophagitis, or pathological hypersecretory condition)(Aciphex) (Aciphex Sprinkle) |
| risperidone (avoid use, except in schizophrenia or bipolar disorder)(Perseris Kit) (Risperdal) (Risperdal Consta) |
| scopolamine (Transderm-Scop) |
| secobarbital (Seconal) |
| sulindac |
| temazepam (Restoril) |
| terazosin (avoid using for treatment of hypertension) |
| testosterone (avoid unless used for confirmed hypogonadism)(Androderm) (Androgel) (Aveed) (Fortesta) (Natesto) (Striant) (Testim) (Vogelxo) (Xyosted) |
| thioridazine (avoid use, except in schizophrenia) |
| thiothixene (avoid use, except in schizophrenia) |
| tolmetin |
| triazolam (Halcion) |
| trifluoperazine (avoid use, except in schizophrenia) |
| trihexyphenidyl |
| trimipramine |
| triprolidine |
| zaleplon (Sonata) |
| ziprasidone (avoid use, except in schizophrenia or bipolar disorder)(Geodon) |
| zolpidem (Ambien) (Ambien CR) (Edluar) (Intermezzo) (Zolpimist) |