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Indications

BEERS REMS

Unlabeled Uses:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: sweating.

Endo: SIADH.

F and E: hyponatremia.

GI: diarrhea, nausea, abdominal pain, constipation, dry mouth, indigestion.

GU: libido, delayed/absent orgasm, ejaculatory delay/failure, erectile dysfunction.

Hemat: BLEEDING.

Metab: appetite.

Neuro: insomnia, dizziness, drowsiness, fatigue, NEUROLEPTIC MALIGNANT SYNDROME, SUICIDAL THOUGHTS.
Misc: SEROTONIN SYNDROME.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

Major Depressive Disorder

Hepatic Impairment

Generalized Anxiety Disorder

Hepatic Impairment

US Brand Names

Lexapro

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antidepressants

Pharmacologic Classification: selective serotonin reuptake inhibitors ssris

Pharmacokinetics

Absorption: 80% absorbed following oral administration.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Mostly metabolized by the liver, primarily by the CYP3A4 and CYP2C19 isoenzymes; 7% excreted unchanged by kidneys.

Half-life: 27–32 hr ( in older adults and hepatic impairment).

Canadian Brand Names

Cipralex

Time/Action Profile

(antidepressant effect)

ROUTEONSETPEAKDURATION
POwithin 1–4 wkunknownunknown

Patient/Family Teaching

Pronunciation

ess-sit-AL-o-pram

Pill Image

escitalopramoxalate_319_131.jpg