section name header

Pronunciation ⬇

kee-TOE-role-ak

Classifications ⬆ ⬇

Therapeutic Classification: nonopioid analgesics

Pharmacologic Classification: nonsteroidal anti inflammatory drugs nsaids

Indications ⬆ ⬇

BEERS REMS


Action ⬆ ⬇

  • Inhibits prostaglandin synthesis, producing peripherally mediated analgesia.
  • Also has antipyretic and anti-inflammatory properties.
Therapeutic effects:
  • Decreased pain.

Pharmacokinetics ⬆ ⬇

Absorption: Rapidly and completely absorbed following all routes of administration.

Distribution: Well distributed to tissues.

Protein Binding: 99%.

Metabolism/Excretion: Primarily metabolized by the liver. Primarily by the kidneys (92%); 6% excreted in feces.

Half-Life: 4.5 hr (range 3.8–6.3 hr; ↑ in geriatric patients and patients with impaired renal function).

Time/Action Profile ⬆ ⬇

(analgesic effects)

ROUTEONSETPEAKDURATION
POunknown2–3 hr4–6 hr or longer
IM, IV10 min1–2 hr6 hr or longer
INunknownunknown6–8 hr or longer

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: edema, HF, MI

Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), EXFOLIATIVE DERMATITIS, pruritus, purpura, STEVENS-JOHNSON SYNDROME, sweating, TOXIC EPIDERMAL NECROLYSIS, urticaria

EENT: ↑lacrimation (spray), nasal discomfort (spray), throat irritation (spray)

F and E: hyperkalemia

GI: ↑liver enzymes, abdominal pain, abnormal taste, diarrhea, dry mouth, dyspepsia, GI BLEEDING, nausea

GU: oliguria, renal toxicity, urinary frequency

Hemat: prolonged bleeding time

Local: injection site pain

Neuro: drowsiness, abnormal thinking, dizziness, euphoria, headache, paresthesia, STROKE

Resp: asthma, dyspnea

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS)

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

IV Administration:

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Sprix, Toradol

Canadian Brand Names ⬆ ⬇

Toradol

Code ⬆

NDC Code