section name header

Pronunciation

zi-PRA-si-done

Classifications

Therapeutic Classification: antipsychotics, mood stabilizers

Pharmacologic Classification: piperazine derivatives

Indications

BEERS REMS


Action

  • Effects probably mediated by antagonism of dopamine type 2 (D2) and serotonin type 2 (5-HT2). Also antagonizes α2 adrenergic receptors.
Therapeutic effects:
  • Diminished schizophrenic behavior.
  • Reduced symptoms of mania.

Pharmacokinetics

Absorption: 60% absorbed following oral administration; 100% absorbed from IM sites.

Distribution: Well distributed to tissues.

Protein Binding: 99%.

Metabolism/Excretion: 99% metabolized by the liver; <1% excreted unchanged in urine.

Half-Life: PO: 7 hr; IM: 2–5 hr.

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
POwithin hrs1–3 daysunknown
IMrapid60 minunknown



Steady state achieved following continuous use.

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: orthostatic hypotension, QT interval prolongation

Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), rash, STEVENS-JOHNSON SYNDROME (SJS), urticaria

EENT: rhinorrhea

Endo: galactorrhea, hyperglycemia

GI: constipation, diarrhea, nausea, dysphagia

GU: amenorrhea, impotence

Hemat: AGRANULOCYTOSIS, leukopenia, neutropenia

Metab: hyperlipidemia, weight gain

Neuro: dizziness, drowsiness, restlessness, extrapyramidal reactions, NEUROLEPTIC MALIGNANT SYNDROME, seizures, syncope, tardive dyskinesia

Resp: cough

Interactions

Drug-drug:

Route/Dosage

Schizophrenia

Acute Manic or Mixed Episodes Associated with Bipolar I Disorder

Maintenance Treatment of Bipolar I Disorder (as adjunct to lithium or valproate)

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Geodon

Canadian Brand Names

Zeldox

Code

NDC Code