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Indications ⬇

REMS

Unlabeled Use:

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: rash, STEVENS-JOHNSON SYNDROME (SJS), urticaria.
topical only: burning, mild dryness, skin irritation, transient redness.

EENT: optic neuropathy, tearing (topical only).

GI: abdominal pain, anorexia, nausea, diarrhea, dry mouth, furry tongue, glossitis, unpleasant taste, vomiting.

Hemat: leukopenia.

Local: phlebitis at IV site.

Neuro: dizziness, headache, aseptic meningitis (IV), encephalopathy (IV), peripheral neuropathy, psychosis, SEIZURES.

Misc: superinfection.

Interactions ⬆ ⬇

Drug-Drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

see Calculator

US Brand Names ⬆ ⬇

Flagyl, MetroCream, MetroGel, MetroLotion, Noritate, Nuvessa, Vandazole

Action ⬆ ⬇

Therapeutic Effects:

Spectrum:

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives, antiprotozoals, antiulcer agents

Pharmacokinetics ⬆ ⬇

Absorption: 80% absorbed after oral administration. Minimal absorption after topical or vaginal application.

Distribution: Widely distributed into most tissues and fluids, including CSF.

Metabolism/Excretion: Partially metabolized by the liver (30–60%), partially excreted unchanged in the urine, 6–15% eliminated in the feces.

Half-life: Neonates: 25–75 hr; Children and adults: 6–12 hr.

Canadian Brand Names ⬆ ⬇

Nidagel

Time/Action Profile ⬆ ⬇

(PO, IV = blood levels; topical = improvement in rosacea)

ROUTEONSETPEAKDURATION
POrapid1–3 hr8 hr
PO-ERrapidunknownup to 24 hr
IVrapidend of infusion6–8 hr
Topical3 wk9 wk12 hr
Vaginalunknown6–12 hr12 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

me-troe-NI-da-zole audio

Code ⬆

NDC Code*