ess-sit-AL-o-pram 
Unlabeled Use:
Contraindicated in:
Use Cautiously in:
Derm: sweating.
Endo: SIADH.
F and E: hyponatremia.
GI: diarrhea, nausea, abdominal pain, constipation, dry mouth, indigestion.
GU: ↓ libido, delayed/absent orgasm, ejaculatory delay/failure, erectile dysfunction.
Hemat: BLEEDING.
Metab: ↑ appetite.
Neuro: insomnia, dizziness, drowsiness, fatigue, NEUROLEPTIC MALIGNANT SYNDROME, SUICIDAL THOUGHTS.
Misc: SEROTONIN SYNDROME.
Drug-Drug:
Drug-Natural Products:
Major Depressive Disorder
Hepatic Impairment
Generalized Anxiety Disorder
Hepatic Impairment
Therapeutic Classification: antidepressants
Pharmacologic Classification: selective serotonin reuptake inhibitors ssris
Absorption: 80% absorbed following oral administration.
Distribution: Enters breast milk.
Metabolism/Excretion: Mostly metabolized by the liver, primarily by the CYP3A4 and CYP2C19 isoenzymes; 7% excreted unchanged by kidneys.
Half-life: 27–32 hr (↑ in elderly and hepatic impairment).
NDC Code*
