TORE-se-mide 
Contraindicated in:
Use Cautiously in:
CV: hypotension.
Derm: photosensitivity, rash, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN).
EENT: hearing loss, tinnitus.
Endo: hyperglycemia.
F and E: dehydration, hypochloremia, hypokalemia, hypomagnesemia, hyponatremia, hypovolemia, metabolic alkalosis, hypocalcemia.
GI: constipation, diarrhea, dry mouth, dyspepsia, nausea, vomiting.
GU: acute renal failure, excessive urination, renal impairment.
Metab: hyperuricemia.
MS: arthralgia, muscle cramps, myalgia.
Neuro: dizziness, headache, nervousness.
Drug-Drug:
Hepatic Cirrhosis
Hypertension
Demadex, Soaanz
Absorption: 80% absorbed after oral administration.
Distribution: Widely distributed to tissues.
Protein Binding: ≥99%.
Metabolism/Excretion: Primarily metabolized by the liver via the CYP2C9 isoenzyme, with minor metabolism via the CYP2C8 and CYP2C18 isoenzymes. 80% metabolized by liver, 20% excreted in urine.
Half-life: 3.5 hr.
NDC Code*