bosutinib

Contraindicated in:

Hypersensitivity;
Concurrent use of moderate to strong CYP3A4 inhibitors or inducers (may significantly alter drug effects);
OB: Pregnancy (may cause fetal harm);
Lactation: Lactation.

Use Cautiously in:

Hepatic impairment (dose ↓ recommended);
Renal impairment (dose ↓ recommended);
Rep: Women of reproductive potential;
Pedi: Safety and effectiveness not established in children.

Adv. Reactions/Side Effects ⬆ ⬇

CV: HF, QT interval prolongation, chest pain, myocardial ischemia, pericardial effusion, pericarditis, peripheral edema

Derm: itching, rash, acne, STEVENS-JOHNSON SYNDROME

EENT: tinnitus

Endo: hypothyroidism

F and E: dehydration, hyperkalemia

GI: ↓appetite, ↑liver enzymes, abdominal pain, diarrhea, nausea, vomiting, GI bleeding, gastritis, HEPATOTOXICITY, pancreatitis

GU: ↓fertility, renal impairment

Hemat: anemia, neutropenia, thrombocytopenia

MS: arthralgia, back pain, myalgia

Neuro: dizziness, fatigue, headache, dysgeusia

Resp: cough, pulmonary edema

Misc: fever, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS)

Interactions ⬆ ⬇

Drug-drug:

Concurrent use of moderate to strong CYP3A4 inhibitors, including aprepitant, atazanavir, ciprofloxacin, clarithromycin, conivaptan, crizotinib, darunavir, diltiazem, erythromycin, fluconazole, fosamprenavir, imatinib, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, posaconazole, ritonavir, verapamil and voriconazole, ↑ blood levels and risk of toxicity and should be avoided.
Concurrent use with moderate to strong CYP3A4 inducers, including bosentan, carbamazepine, efavirenz, etravirine, modafinil, nafcillin, phenobarbital, phenytoin, rifabutin and rifampin, may ↓ blood levels and beneficial effects and should be avoided.
Proton pump inhibitors, including esomeprazole, dexlansoprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole, may ↓ blood levels and effectiveness and should be avoided, consider using short-acting antacids or histamine-H₂ receptor blockers instead (these should be taken 2 hr before or 2 hr after bosutinib).
May ↑ digoxin levels.

Drug-Natural Products:

Concurrent use with St. John's wort may ↓ blood levels and beneficial effects and should be avoided.

Drug-Food:

Grapefruit juice may ↑ blood levels and the risk of toxicity and should be avoided.

Availability ⬆ ⬇

Tablets: 100 mg; 400 mg; 500 mg

Route/Dosage ⬆ ⬇

Chronic/Accelerated/Blast Phase Ph+ CML Resistant/Intolerant to Previous Therapies

PO (Adults ): 500 mg once daily, if complete hematologic response has not occurred by 8 wk, or complete cytologic response by 12 wk or there has been no occurrence of ≥Grade 3 adverse reactions, consider ↑ dose to 600 mg once daily. Continue until disease progression or unacceptable toxicity.

Hepatic Impairment

PO (Adults ): Any degree of hepatic impairment: 200 mg once daily.

Renal Impairment

PO (Adults ): CCr 30–50 mL/min: 400 mg once daily; CCr <30 mL/min: 300 mg once daily.

Newly Diagnosis Ph+ CML

PO (Adults ): 400 mg once daily, if complete hematologic response has not occurred by 8 wk, or complete cytologic response by 12 wk or there has been no occurrence of ≥Grade 3 adverse reactions, consider ↑ dose in 100–mg/day increments up to maximum dose of 600 mg once daily. Continue until disease progression or unacceptable toxicity.

Hepatic Impairment

PO (Adults ): Any degree of hepatic impairment: 200 mg once daily.

Renal Impairment

PO (Adults ): CCr 30–50 mL/min: 300 mg once daily; CCr <30 mL/min: 200 mg once daily.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Acts as a kinase inhibitor, specifically inhibiting the kinase that promotes CML.

Therapeutic effects:

Decreased progression of CML.

Classifications ⬆ ⬇

Therapeutic Classification: antineoplastics

Pharmacologic Classification: kinase inhibitors

Pharmacokinetics ⬆ ⬇

Absorption: Absorbed following oral administration

Distribution: Unknown.

Protein Binding: 96%

Metabolism/Excretion: Mostly metabolized, mainly by the CYP3A4 enzyme system; metabolites do not have antineoplastic activity.

Half-Life: 22.5 hr

Time/Action Profile ⬆ ⬇

(beneficial hematologic response)

ROUTE	ONSET	PEAK	DURATION
PO	within 8–12 wk	4–6 hr (blood level)	9–18 mo or longer

Patient/Family Teaching ⬆ ⬇

Instruct patient to take bosutinib as directed. Take missed doses as soon as remembered if within 12 hours, if longer than 12 hrs skip dose and take usual prescribed dose on the following day. Do not stop taking bosutinib without consulting health care professional. Advise patient to read Patient Information before starting therapy and with each Rx refill in case of changes.
Advise patient to avoid grapefruit and grapefruit juice during therapy.
Advise patient to immediately report fever, jaundice (skin or the white part of your eyes turns yellow or dark “tea color” urine), symptoms of infection, fluid retention, anaphylaxis, rash, unexpected bleeding or bruising, or blood in urine or stools occur. Advise patient to notify health care professional if diarrhea, nausea, vomiting, abdominal pain occur.
Inform patient to take medications that decrease stomach acid (antacids and H₂ blockers) 2 hrs before or 2 hrs after bosutinib and to consult health care professional if taking a proton pump inhibitor (PPI).
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications, especially St. John's wort.
Rep: May cause fetal harm. Advise females of reproductive potential to use effective contraception and to avoid breastfeeding during and for at least 2 wk after last dose of therapy. Advise patient to notify health care professional immediately if pregnancy is suspected. May impair fertility in male and female patients.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

0069- Pfizer Laboratories Div Pfizer Inc
- 0069-0135- BOSULIF
  - 0069-0135-01- 120 TABLET, FILM COATED in 1 BOTTLE (0069-0135-01)

0069- Pfizer Laboratories Div Pfizer Inc
- 0069-0136- BOSULIF
  - 0069-0136-01- 30 TABLET, FILM COATED in 1 BOTTLE (0069-0136-01)

0069- Pfizer Laboratories Div Pfizer Inc
- 0069-0193- BOSULIF
  - 0069-0193-01- 30 TABLET, FILM COATED in 1 BOTTLE (0069-0193-01)

63539- U.S. Pharmaceuticals
- 63539-117- BOSULIF
  - 63539-117-01- 120 TABLET, FILM COATED in 1 BOTTLE (63539-117-01)

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Indications ⬇

Contraind./Precautions ⬆ ⬇