- PO (Adults ): 200–400 mg/day, single dose.
- PO (Children >2 yr): 3.3–6.6 mg/kg/day, single dose.
REMS
Contraindicated in:
Use Cautiously in:
CV: QT interval prolongation, TORSADES DE POINTES
Derm: rash, urticaria
EENT: photophobia
Endo: adrenal insufficiency, gynecomastia
GI: nausea, vomiting, abdominal pain, constipation, diarrhea, flatulence, HEPATOTOXICITY
GU: ↓male libido, azoospermia, menstrual irregularities, oligospermia
Neuro: dizziness, drowsiness
Misc: ANAPHYLAXIS
Drug-drug:
Spectrum:
Absorption: Absorption from the GI tract is pH dependent; increasing pH decreases absorption.
Distribution: Widely distributed. CNS penetration is unpredictable and minimal. Crosses the placenta; enters breast milk.
Protein Binding: 99%.
Half-Life: 8 hr.
NDC Code