tranexamic acid

High Alert

IV: Prevention or reduction of hemorrhage during and following dental surgery in hemophiliacs.
PO: Cyclic heavy menstrual bleeding.

Contraindicated in:

Hypersensitivity;
Thromboembolic disorders (current, history of, or at risk for);
Acquired defective color vision (IV);
Subarachnoid hemorrhage;
Concurrent use of combination hormonal contraception (PO).

Use Cautiously in:

Renal impairment (↑ dosing interval);
Hematuria originating in the upper urinary tract;
Conditions associated with ↑ thrombus formation;
OB: Use during pregnancy only if potential maternal benefit justifies potential fetal risk;
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant.

CV: hypotension, thromboembolism

EENT: visual abnormalities

GI: diarrhea, nausea, vomiting

MS: pain

Neuro: headache, dizziness, SEIZURES

Misc: POANAPHYLAXIS

Drug-drug:

Concurrent use of hormonal contraceptives with oral tranexamic acid may ↑ risk of thrombosis; concurrent use contraindicated.
Concurrent use of clotting factor complexes may ↑ the risk of thrombotic complications (give tranexamic acid 8 hr following clotting factor replacement therapy).
May ↑ the procoagulant effects of all-trans retinoic acid.
↓effectiveness with thrombolytic agents.

(Generic available)

Premixed infusion: 1 g/100 mL 0.7% NaCl
Solution for injection: 100 mg/mL
Tablets: 500 mg; 650 mg

IV (Adults and Children ): 10 mg/kg just prior to surgery with appropriate replacement therapy; then 10 mg/kg 3–4 times daily for 2–8 days.

Renal Impairment

IV (Adults and Children ): SCr 1.36–2.83 mg/dL: 10 mg/kg twice daily; SCr 2.83–5.66 mg/dL: 10 mg/kg daily; SCr >5.66 mg/dL: 10 mg/kg every 48 hr or 5 mg/kg once daily.
PO (Adults ): 1300 mg 3 times daily for a maximum of 5 days during menstruation.

Renal Impairment

PO (Adults ): SCr 1.41–2.8 mg/dL: 1300 mg twice daily for a maximum of 5 days during menstruation; SCr 2.81–5.7 mg/dL: 1300 mg daily for a maximum of 5 days during menstruation; SCr >5.7 mg/dL: 650 mg daily for a maximum of 5 days during menstruation.

Cyklokapron, Lysteda

Inhibits activation of plasminogen, thereby preventing the conversion of plasminogen to plasmin.

Therapeutic effects:

Decreased bleeding following dental surgery in hemophiliacs.
Reduced need for replacement therapy.
Reduced menstrual blood loss.

Therapeutic Classification: hemostatic agents

Pharmacologic Classification: antifibrinolytics, plasminogen inactivators

Absorption: IV administration results in complete bioavailability; 45% absorbed following oral administration.

Distribution: Penetrates readily into joint fluid and synovial membranes.

Metabolism/Excretion: 95% excreted unchanged in urine.

Half-Life: IV: 2 hr (↑ in renal impairment); Oral: 11 hr.

( plasma concentrations)

ROUTE		ONSET		PEAK		DURATION
IV		unknown		unknown		7–8 hr
PO		unknown		2.5 hr		unknown

Instruct patient to take medication as directed; do not take more than 6 tablets/day, for longer that 5 days in any menstrual cycle, or when not menstruating. Take missed doses as soon as remembered; then take next dose as least 6 hr later; do not double doses. Advise patient to read Patient Information before starting and with each Rx refill in case of changes.
Advise patient to stop medication and inform health care professional of any changes in vision. Inform patients on prolonged therapy of the importance of regular ophthalmologic follow-up.
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications. Caution patient to avoid taking hormonal contraceptives and products containing aspirin or NSAIDs without consulting health care professional.
Instruct patient to notify health care professional if signs and symptoms of thrombosis (severe, sudden headache; pains in chest, groin, or legs, especially calves; sudden loss of coordination; sudden and unexplained shortness of breath; slurred speech; visual changes; weakness or numbness in arm or leg) or anaphylaxis (shortness of breath, throat tightness, rash) occur.
Instruct patient to notify health care professional if heavy menstrual bleeding persists or worsens or if bleeding does not lessen after 2 cycles or tranexamic acid seems to stop working.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

tran-ex-AM-ikAS-id

NDC Code

0013- Pfizer Laboratories Div Pfizer Inc
- 0013-1114- Cyklokapron
  - 0013-1114-15- 1 AMPULE in 1 CARTON (0013-1114-15) / 10 mL in 1 AMPULE (0013-1114-01)

0013- Pfizer Laboratories Div Pfizer Inc
- 0013-1114- Cyklokapron
  - 0013-1114-21- 10 VIAL in 1 BOX (0013-1114-21) / 10 mL in 1 VIAL (0013-1114-20)

0517- American Regent, Inc.
- 0517-0960- Tranexamic Acid
  - 0517-0960-01- 1 VIAL, GLASS in 1 CARTON (0517-0960-01) / 10 mL in 1 VIAL, GLASS

0517- American Regent, Inc.
- 0517-0960- Tranexamic Acid
  - 0517-0960-10- 10 VIAL, GLASS in 1 CARTON (0517-0960-10) / 10 mL in 1 VIAL, GLASS

0591- Actavis Pharma, Inc.
- 0591-3720- Tranexamic Acid
  - 0591-3720-10- 1000 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (0591-3720-10)

0591- Actavis Pharma, Inc.
- 0591-3720- Tranexamic Acid
  - 0591-3720-30- 30 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (0591-3720-30)

12079- Kyowa Pharma Chemical Co., Ltd.
- 12079-2001-
  - 12079-2001-1- 25 kg in 1 DRUM (12079-2001-1)

12079- Kyowa Pharma Chemical Co., Ltd.
- 12079-2001-
  - 12079-2001-2- 50 kg in 1 DRUM (12079-2001-2)

12848- Asahi Kasei Finechem Co., Ltd.
- 12848-1004-
  - 12848-1004-2- 25 kg in 1 DRUM (12848-1004-2)

14537- TERUMO BCT LTD
- 14537-115-
  14537-115-30- 30 BAG in 1 BOX (14537-115-30) / 100 mL in 1 BAG

14593- Emcure Pharmaceuticals Limited
- 14593-318- Tranexamic Acid
  14593-318-01- 10 VIAL in 1 CARTON (14593-318-01) / 10 mL in 1 VIAL

14789- Nexus Pharmaceuticals LLC
- 14789-115- Tranexamic Acid
  - 14789-115-05- 10 BAG in 1 CARTON (14789-115-05) / 100 mL in 1 BAG (14789-115-08)

23155- Heritage Pharmaceuticals Labs Inc. d/b/a Avet Pharmaceuticals Labs Inc.
- 23155-166- Tranexamic Acid
  - 23155-166-41- 10 VIAL, GLASS in 1 CARTON (23155-166-41) / 10 mL in 1 VIAL, GLASS (23155-166-31)

23155- Heritage Pharmaceuticals Labs Inc. d/b/a Avet Pharmaceuticals Labs Inc.
- 23155-524- Tranexamic Acid
  - 23155-524-41- 10 VIAL, GLASS in 1 CARTON (23155-524-41) / 10 mL in 1 VIAL, GLASS (23155-524-31)

23155- Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
- 23155-909- Tranexamic Acid
  - 23155-909-41- 10 AMPULE in 1 CARTON (23155-909-41) / 10 mL in 1 AMPULE

23155- Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
- 23155-910- Tranexamic Acid
  - 23155-910-41- 10 VIAL, SINGLE-DOSE in 1 CARTON (23155-910-41) / 10 mL in 1 VIAL, SINGLE-DOSE

25021- Sagent Pharmaceuticals
- 25021-415- Tranexamic Acid
  - 25021-415-10- 10 VIAL in 1 CARTON (25021-415-10) / 10 mL in 1 VIAL

25021- Sagent Pharmaceuticals
- 25021-418- Tranexamic Acid
  - 25021-418-82- 10 BAG in 1 CARTON (25021-418-82) / 100 mL in 1 BAG

38779- Medisca Inc.
- 38779-2794-
  - 38779-2794-2- 50 g in 1 VIAL (38779-2794-2)

38779- Medisca Inc.
- 38779-2794-
  38779-2794-4- 25 g in 1 VIAL (38779-2794-4)

38779- Medisca Inc.
- 38779-2794-
  38779-2794-5- 100 g in 1 VIAL (38779-2794-5)

38779- Medisca Inc.
- 38779-2794-
  38779-2794-8- 500 g in 1 JAR (38779-2794-8)

38779- Medisca Inc.
- 38779-2794-
  38779-2794-9- 1000 g in 1 JAR (38779-2794-9)

38779- Medisca Inc.
- 38779-3211-
  38779-3211-2- 50 g in 1 BOTTLE, GLASS (38779-3211-2)

38779- Medisca Inc.
- 38779-3211-
  38779-3211-4- 25 g in 1 BOTTLE, GLASS (38779-3211-4)

38779- Medisca Inc.
- 38779-3211-
  38779-3211-5- 100 g in 1 BOTTLE, GLASS (38779-3211-5)

38779- Medisca Inc.
- 38779-3211-
  38779-3211-7- 25000 g in 1 DRUM (38779-3211-7)

38779- Medisca Inc.
- 38779-3211-
  38779-3211-8- 500 g in 1 JAR (38779-3211-8)

38779- Medisca Inc.
- 38779-3211-
  38779-3211-9- 1000 g in 1 JAR (38779-3211-9)

39822- XGen Pharmaceuticals DJB, Inc.
- 39822-1000- Tranexamic Acid
  39822-1000-1- 10 VIAL in 1 CARTON (39822-1000-1) / 10 mL in 1 VIAL

42571- Micro Labs Limited
- 42571-189- Tranexamic Acid
  - 42571-189-57- 10 CARTON in 1 CARTON (42571-189-57) / 1 AMPULE in 1 CARTON (42571-189-56) / 10 mL in 1 AMPULE

42571- Micro Labs Limited
- 42571-314- Tranexamic Acid
  - 42571-314-89- 10 CARTON in 1 CARTON (42571-314-89) / 1 VIAL, GLASS in 1 CARTON (42571-314-88) / 10 mL in 1 VIAL, GLASS

43066- Baxter Healthcare Corporation
- 43066-008- TRANEXAMIC ACID
  - 43066-008-10- 10 CARTON in 1 BOX (43066-008-10) / 1 VIAL, SINGLE-DOSE in 1 CARTON / 10 mL in 1 VIAL, SINGLE-DOSE (43066-008-01)

47554- Changzhou Yinsheng Pharmaceutical Co. Ltd.
- 47554-001-
  - 47554-001-00- 1 BAG in 1 DRUM (47554-001-00) / 25 kg in 1 BAG

49452- Spectrum Laboratory Products, Inc.
- 49452-7876-
  49452-7876-1- 5 g in 1 BOTTLE, GLASS (49452-7876-1)

49452- Spectrum Laboratory Products, Inc.
- 49452-7876-
  49452-7876-2- 25 g in 1 BOTTLE, GLASS (49452-7876-2)

49452- Spectrum Laboratory Products, Inc.
- 49452-7876-
  49452-7876-3- 100 g in 1 BOTTLE, GLASS (49452-7876-3)

49452- Spectrum Laboratory Products, Inc.
- 49452-7876-
  49452-7876-4- 1000 g in 1 BOTTLE, GLASS (49452-7876-4)

49452- Spectrum Laboratory Products, Inc.
- 49452-7876-
  49452-7876-5- 5000 g in 1 PAIL (49452-7876-5)

50268- AvPAK
- 50268-772- Tranexamic Acid
  50268-772-13- 30 BLISTER PACK in 1 BOX (50268-772-13) / 1 TABLET in 1 BLISTER PACK (50268-772-11)

51552- Fagron Inc
- 51552-0513-
  - 51552-0513-5- 100 g in 1 CONTAINER (51552-0513-5)

51552- Fagron Inc
- 51552-0513-
  51552-0513-9- 50 g in 1 CONTAINER (51552-0513-9)

51662- HF Acquisition Co LLC, DBA HealthFirst
- 51662-1532- TRANEXAMIC ACID
  51662-1532-1- 10 mL in 1 VIAL, SINGLE-DOSE (51662-1532-1)

51662- HF Acquisition Co LLC, DBA HealthFirst
- 51662-1532- TRANEXAMIC ACID
  - 51662-1532-3- 10 POUCH in 1 CASE (51662-1532-3) / 1 VIAL, SINGLE-DOSE in 1 POUCH (51662-1532-2) / 10 mL in 1 VIAL, SINGLE-DOSE

51754- Exela Pharma Sciences, LLC
- 51754-0108- TRANEXAMIC ACID IN SODIUM CHLORIDE
  - 51754-0108-1- 100 mL in 1 BAG (51754-0108-1)

51754- Exela Pharma Sciences, LLC
- 51754-0108- TRANEXAMIC ACID IN SODIUM CHLORIDE
  - 51754-0108-3- 1000 mL in 1 CASE (51754-0108-3)

51927- Professional Compounding Centers of America dba PCCA
- 51927-0022-
  - 51927-0022-0- 1 kg in 1 CONTAINER (51927-0022-0)

55150- Eugia US LLC
- 55150-188- Tranexamic Acid
  55150-188-10- 10 VIAL, SINGLE-DOSE in 1 CARTON (55150-188-10) / 10 mL in 1 VIAL, SINGLE-DOSE

57218- Malladi Drugs & Pharmaceuticals Limited
- 57218-951-
  - 57218-951-01- 5 kg in 1 DRUM (57218-951-01)

57218- Malladi Drugs & Pharmaceuticals Limited
- 57218-951-
  57218-951-02- 10 kg in 1 DRUM (57218-951-02)

57218- Malladi Drugs & Pharmaceuticals Limited
- 57218-951-
  57218-951-03- 15 kg in 1 DRUM (57218-951-03)

57218- Malladi Drugs & Pharmaceuticals Limited
- 57218-951-
  57218-951-04- 25 kg in 1 DRUM (57218-951-04)

57218- Malladi Drugs & Pharmaceuticals Limited
- 57218-951-
  57218-951-05- 3.5 kg in 1 DRUM (57218-951-05)

59651- Aurobindo Pharma Limited
- 59651-839- TRANEXAMIC ACID
  59651-839-30- 30 TABLET in 1 BOTTLE (59651-839-30)

59680- Ami Lifesciences Private Limited
- 59680-012-
  - 59680-012-00- 25 kg in 1 DRUM (59680-012-00)

60505- Apotex Corp.
- 60505-6169- Tranexamic Acid
  60505-6169-1- 10 VIAL in 1 CARTON (60505-6169-1) / 10 mL in 1 VIAL

60592- KALCHEM INTERNATIONAL INC
- 60592-913-
  - 60592-913-10- 1000 g in 1 BOTTLE (60592-913-10)

60687- American Health Packaging
- 60687-750- Tranexamic Acid
  60687-750-21- 30 BLISTER PACK in 1 CARTON (60687-750-21) / 1 TABLET in 1 BLISTER PACK (60687-750-11)

62559- ANI Pharmaceuticals, Inc.
- 62559-265- Tranexamic Acid
  - 62559-265-30- 30 TABLET in 1 BOTTLE (62559-265-30)

62991- LETCO MEDICAL, LLC
- 62991-3131-
  - 62991-3131-1- 25 g in 1 JAR (62991-3131-1)

62991- LETCO MEDICAL, LLC
- 62991-3131-
  62991-3131-2- 100 g in 1 JAR (62991-3131-2)

62991- LETCO MEDICAL, LLC
- 62991-3131-
  62991-3131-3- 1000 g in 1 JAR (62991-3131-3)

62991- LETCO MEDICAL, LLC
- 62991-3131-
  62991-3131-4- 25000 g in 1 DRUM (62991-3131-4)

63323- Fresenius Kabi USA, LLC
- 63323-563- Tranexamic Acid
  63323-563-10- 10 VIAL in 1 TRAY (63323-563-10) / 10 mL in 1 VIAL (63323-563-01)

63629- Bryant Ranch Prepack
- 63629-8599- Tranexamic Acid
  - 63629-8599-1- 8 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (63629-8599-1)

63629- Bryant Ranch Prepack
- 63629-8838- Tranexamic Acid
  - 63629-8838-1- 30 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (63629-8838-1)

65145- Caplin Steriles Limited
- 65145-106- Tranexamic Acid
  - 65145-106-10- 10 VIAL in 1 BOX (65145-106-10) / 10 mL in 1 VIAL (65145-106-01)

65219- Fresenius Kabi USA, LLC
- 65219-534- TRANEXAMIC ACID IN SODIUM CHLORIDE
  - 65219-534-10- 24 BAG in 1 CASE (65219-534-10) / 100 mL in 1 BAG (65219-534-01)

65388- Hunan Dongting Pharmaceutical Co., Ltd
- 65388-0156-
  - 65388-0156-1- 1 BAG in 1 DRUM (65388-0156-1) / 25 kg in 1 BAG (65388-0156-2)

66298- HP Halden Pharma AS
- 66298-5340- Tranexamic Acid in Sodium Chloride
  66298-5340-1- 24 BAG in 1 CASE (66298-5340-1) / 100 mL in 1 BAG

67457- Mylan Institutional LLC
- 67457-197- Tranexamic Acid
  - 67457-197-10- 10 VIAL, SINGLE-DOSE in 1 PACKAGE (67457-197-10) / 10 mL in 1 VIAL, SINGLE-DOSE (67457-197-00)

67850- Methapharm, Inc.
- 67850-041- Tranexamic Acid
  - 67850-041-10- 10 VIAL, SINGLE-USE in 1 CARTON (67850-041-10) / 10 mL in 1 VIAL, SINGLE-USE (67850-041-00)

67850- Methapharm, Inc.
- 67850-042- Tranexamic Acid
  - 67850-042-10- 10 AMPULE in 1 CARTON (67850-042-10) / 10 mL in 1 AMPULE (67850-042-00)

68083- Gland Pharma Limited
- 68083-160- Tranexamic acid
  - 68083-160-10- 10 VIAL in 1 CARTON (68083-160-10) / 10 mL in 1 VIAL

68083- Gland Pharma Limited
- 68083-613- TRANEXAMIC ACID IN SODIUM CHLORIDE
  - 68083-613-10- 10 POUCH in 1 CARTON (68083-613-10) / 1 BAG in 1 POUCH / 100 mL in 1 BAG

69918- Nordic Pharma, Inc.
- 69918-301- Tranexamic Acid
  - 69918-301-30- 30 TABLET in 1 BOTTLE (69918-301-30)

70121- Amneal Pharmaceuticals LLC
- 70121-1398- Tranexamic Acid
  - 70121-1398-1- 1 VIAL, SINGLE-DOSE in 1 CARTON (70121-1398-1) / 10 mL in 1 VIAL, SINGLE-DOSE

70518- REMEDYREPACK INC.
- 70518-4089- TRANEXAMIC ACID
  - 70518-4089-0- 10 CARTON in 1 BOX (70518-4089-0) / 1 VIAL, SINGLE-DOSE in 1 CARTON / 10 mL in 1 VIAL, SINGLE-DOSE (70518-4089-1)

70860- Athenex Pharmaceutical Division, LLC.
- 70860-407- Tranexamic Acid
  - 70860-407-10- 10 VIAL, SINGLE-DOSE in 1 CARTON (70860-407-10) / 10 mL in 1 VIAL, SINGLE-DOSE (70860-407-41)

71052- DARMERICA, LLC
- 71052-166-
  - 71052-166-01- 100 g in 1 CONTAINER (71052-166-01)

71052- DARMERICA, LLC
- 71052-166-
  71052-166-05- 500 g in 1 CONTAINER (71052-166-05)

71052- DARMERICA, LLC
- 71052-166-
  71052-166-09- 9000 g in 1 CONTAINER (71052-166-09)

71052- DARMERICA, LLC
- 71052-166-
  71052-166-10- 10000 g in 1 CONTAINER (71052-166-10)

71052- DARMERICA, LLC
- 71052-166-
  71052-166-11- 1000 g in 1 CONTAINER (71052-166-11)

71052- DARMERICA, LLC
- 71052-166-
  71052-166-25- 25000 g in 1 CONTAINER (71052-166-25)

71052- DARMERICA, LLC
- 71052-166-
  71052-166-55- 5000 g in 1 CONTAINER (71052-166-55)

71335- Bryant Ranch Prepack
- 71335-1957- Tranexamic Acid
  71335-1957-1- 8 TABLET in 1 BOTTLE (71335-1957-1)

71335- Bryant Ranch Prepack
- 71335-1957- Tranexamic Acid
  - 71335-1957-2- 30 TABLET in 1 BOTTLE (71335-1957-2)

71335- Bryant Ranch Prepack
- 71335-1981- Tranexamic Acid
  - 71335-1981-1- 8 TABLET in 1 BOTTLE (71335-1981-1)

71335- Bryant Ranch Prepack
- 71335-1981- Tranexamic Acid
  - 71335-1981-2- 30 TABLET in 1 BOTTLE (71335-1981-2)

71335- Bryant Ranch Prepack
- 71335-1981- Tranexamic Acid
  - 71335-1981-3- 4 TABLET in 1 BOTTLE (71335-1981-3)

71335- Bryant Ranch Prepack
- 71335-2695- TRANEXAMIC ACID
  - 71335-2695-1- 8 TABLET in 1 BOTTLE (71335-2695-1)

71335- Bryant Ranch Prepack
- 71335-2695- TRANEXAMIC ACID
  - 71335-2695-2- 30 TABLET in 1 BOTTLE (71335-2695-2)

71335- Bryant Ranch Prepack
- 71335-2695- TRANEXAMIC ACID
  - 71335-2695-3- 4 TABLET in 1 BOTTLE (71335-2695-3)

72485- Armas Pharmaceuticals Inc.
- 72485-107- TRANEXAMIC ACID
  - 72485-107-01- 1 VIAL, GLASS in 1 CARTON (72485-107-01) / 10 mL in 1 VIAL, GLASS

72485- Armas Pharmaceuticals Inc.
- 72485-107- TRANEXAMIC ACID
  - 72485-107-10- 10 VIAL, GLASS in 1 CARTON (72485-107-10) / 10 mL in 1 VIAL, GLASS

72485- Armas Pharmaceuticals Inc.
- 72485-510- Tranexamic Acid
  - 72485-510-10- 10 VIAL in 1 CARTON (72485-510-10) / 10 mL in 1 VIAL (72485-510-01)

72603- Northstar Rx LLC
- 72603-387- TRANEXAMIC ACID
  - 72603-387-10- 10 VIAL, SINGLE-DOSE in 1 CARTON (72603-387-10) / 10 mL in 1 VIAL, SINGLE-DOSE (72603-387-01)

72888- ADVAGEN PHARMA LIMITED
- 72888-178- TRANEXAMIC ACID
  - 72888-178-01- 100 TABLET in 1 BOTTLE (72888-178-01)

72888- ADVAGEN PHARMA LIMITED
- 72888-178- TRANEXAMIC ACID
  - 72888-178-05- 500 TABLET in 1 BOTTLE (72888-178-05)

72888- ADVAGEN PHARMA LIMITED
- 72888-178- TRANEXAMIC ACID
  - 72888-178-30- 30 TABLET in 1 BOTTLE (72888-178-30)

section name header

Indications ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Classifications ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Time/Action Profile ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

Code ⬆