formoterol

REMS

Maintenance treatment to prevent bronchospasm in chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.

Contraindicated in:

Hypersensitivity;
Asthma;
Acutely deteriorating COPD or acute respiratory symptoms.

Use Cautiously in:

Cardiovascular disease (including angina, hypertension, and arrhythmias);
Diabetes;
Seizure disorders;
Glaucoma;
Hyperthyroidism;
Pheochromocytoma;
Excessive use (may lead to tolerance and paradoxical bronchospasm);
OB: Use during pregnancy only if potential maternal benefit justifies potential fetal risk; may inhibit contractions during labor;
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
Pedi: Safety and effectiveness not established in children.

CV: angina, arrhythmia, hypertension, hypotension, palpitations, tachycardia

Derm: rash

F and E: hypokalemia

GI: dry mouth, nausea

Metab: hyperglycemia, metabolic acidosis

MS: muscle cramps

Neuro: dizziness, fatigue, headache, insomnia, malaise, nervousness, tremor

Resp: PARADOXICAL BRONCHOSPASM

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS)

Drug-drug:

MAO inhibitors, tricyclic antidepressants,, or QT interval prolonging medications may ↑ risk of arrhythmias; avoid concurrent use.
↑risk of hypokalemia with theophylline, corticosteroids, potassium-losing diuretics.
Beta blockers may ↓ therapeutic effects.
↑adrenergic effects may occur with concurrent use of adrenergics.

(Generic available)

Inhalation solution for nebulization (Perforomist): 20 mcg/2 mL
Powder for inhalation (Oxeze Turbuhaler): 6 mcg/inhalation (60 metered doses); 12 mcg/inhalation (60 metered doses)
In combination with:
aclidinium (Duaklir Pressair); budesonide (Breyna, Symbicort); budesonide, glycopyrrolate, and formoterol (Breztri Aerosphere); glycopyrrolate (Bevespi Aerosphere); mometasone (Dulera); see Combination Drugs.

Inhaln (Adults ): 20 mcg twice daily via jet nebulizer.

Produces accumulation of cyclic adenosine monophosphate (cAMP) at beta-adrenergic receptors, resulting in relaxation of airway smooth muscle.
Relatively specific for beta₂ (pulmonary) receptors.

Therapeutic effects:

Bronchodilation.

Therapeutic Classification: bronchodilators

Pharmacologic Classification: adrenergics

Absorption: Following inhalation, majority of inhaled drug is swallowed and absorbed.

Distribution: Unknown.

Metabolism/Excretion: Mostly metabolized by the liver; 10–18% excreted unchanged in urine.

Half-Life: 10 hr.

(bronchodilation)

ROUTE	ONSET	PEAK	DURATION
Inhaln	15 min	1–3 hr	12 hr

Explain purpose and side effects of medication. Advise patient to read Patient Information before starting therapy.
Instruct patient to not discontinue therapy even if feeling better. If a dose is missed, omit and take next regularly scheduled dose. Do not double dose. Use a rapid-acting bronchodilator if symptoms occur before next dose is due. Caution patient not to use more than 2 times a day or <12 hr apart.
Instruct patient to notify health care professional immediately if rash, bronchospasm, shortness of breath not relieved by medication, nausea, vomiting, shakiness, headache, fast or irregular heartbeat, or sleeplessness occur.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other medications or alcohol concurrently.
Caution patient also to avoid smoking and other respiratory irritants.
Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected, or if breastfeeding.

NDC Code

0093- Teva Pharmaceuticals USA, Inc.
- 0093-4061- Formoterol fumarate
  - 0093-4061-06- 60 POUCH in 1 CARTON (0093-4061-06) / 1 VIAL in 1 POUCH / 2 mL in 1 VIAL

0093- Teva Pharmaceuticals USA, Inc.
- 0093-4061- Formoterol fumarate
  - 0093-4061-30- 30 POUCH in 1 CARTON (0093-4061-30) / 1 VIAL in 1 POUCH (0093-4061-19) / 2 mL in 1 VIAL

12780- Fermion Oy
- 12780-4880-
  - 12780-4880-0- 1 BAG in 1 DRUM (12780-4880-0) / 1 BAG in 1 BAG / 1 BOTTLE, GLASS in 1 BAG / .1 kg in 1 BOTTLE, GLASS

14501- MSN Laboratories Private Limited
- 14501-0087-
  - 14501-0087-2- 50 kg in 1 DRUM (14501-0087-2)

38779- Medisca Inc.
- 38779-2295-
  - 38779-2295-0- .5 g in 1 BOTTLE (38779-2295-0)

38779- Medisca Inc.
- 38779-2295-
  38779-2295-3- 5 g in 1 BOTTLE (38779-2295-3)

38779- Medisca Inc.
- 38779-2295-
  38779-2295-4- 25 g in 1 JAR (38779-2295-4)

38779- Medisca Inc.
- 38779-2295-
  38779-2295-6- 1 g in 1 BOTTLE (38779-2295-6)

42571- Micro Labs Limited
- 42571-463- Formoterol fumarate
  42571-463-62- 60 POUCH in 1 CARTON (42571-463-62) / 1 VIAL in 1 POUCH / 2 mL in 1 VIAL

42571- Micro Labs Limited
- 42571-463- Formoterol fumarate
  - 42571-463-73- 30 POUCH in 1 CARTON (42571-463-73) / 1 VIAL in 1 POUCH / 2 mL in 1 VIAL

43598- Dr. Reddy's Laboratories Inc.
- 43598-778- Formoterol Fumarate
  - 43598-778-30- 30 POUCH in 1 CARTON (43598-778-30) / 1 VIAL in 1 POUCH (43598-778-11) / 2 mL in 1 VIAL

43598- Dr. Reddy's Laboratories Inc.
- 43598-778- Formoterol Fumarate
  - 43598-778-60- 60 POUCH in 1 CARTON (43598-778-60) / 1 VIAL in 1 POUCH (43598-778-11) / 2 mL in 1 VIAL

46439- Farmabios S.p.A.
- 46439-8763-
  - 46439-8763-1- 108 g in 1 BOTTLE, GLASS (46439-8763-1)

50742- Ingenus Pharmaceuticals, LLC
- 50742-394- Formoterol Fumarate
  50742-394-30- 30 POUCH in 1 CARTON (50742-394-30) / 1 VIAL, SINGLE-DOSE in 1 POUCH (50742-394-01) / 2 mL in 1 VIAL, SINGLE-DOSE

50742- Ingenus Pharmaceuticals, LLC
- 50742-394- Formoterol Fumarate
  - 50742-394-60- 60 POUCH in 1 CARTON (50742-394-60) / 1 VIAL, SINGLE-DOSE in 1 POUCH / 2 mL in 1 VIAL, SINGLE-DOSE

52221- Amphastar Nanjing Pharmaceuticals, Inc.
- 52221-116-
  - 52221-116-00- 1 CAN in 1 CARTON (52221-116-00) / 1 BAG in 1 CAN / 1000 g in 1 BAG

52221- Amphastar Nanjing Pharmaceuticals, Inc.
- 52221-116-
  52221-116-01- 1 BAG in 1 CAN (52221-116-01) / 500 g in 1 BAG

53104- Cipla Ltd.
- 53104-7530-
  53104-7530-1- 25 kg in 1 DRUM (53104-7530-1)

62332- Alembic Pharmaceuticals Inc.
- 62332-655- Formoterol Fumarate
  62332-655-30- 30 POUCH in 1 CARTON (62332-655-30) / 1 VIAL in 1 POUCH (62332-655-01) / 2 mL in 1 VIAL

62332- Alembic Pharmaceuticals Inc.
- 62332-655- Formoterol Fumarate
  - 62332-655-60- 60 POUCH in 1 CARTON (62332-655-60) / 1 VIAL in 1 POUCH / 2 mL in 1 VIAL

63190- Industriale Chimica s.r.l.
- 63190-0040-
  - 63190-0040-3- 30 kg in 1 DRUM (63190-0040-3)

63190- Industriale Chimica s.r.l.
- 63190-0040-
  63190-0040-5- 1 kg in 1 DRUM (63190-0040-5)

63629- Bryant Ranch Prepack
- 63629-8813- Formoterol fumarate
  63629-8813-1- 30 POUCH in 1 CARTON (63629-8813-1) / 1 VIAL in 1 POUCH / 2 mL in 1 VIAL

63629- Bryant Ranch Prepack
- 63629-8814- Formoterol fumarate
  - 63629-8814-1- 60 POUCH in 1 CARTON (63629-8814-1) / 1 VIAL in 1 POUCH / 2 mL in 1 VIAL

66412- VAMSI LABS LIMITED.
- 66412-0204-
  - 66412-0204-1- 10 g in 1 BAG (66412-0204-1)

66412- VAMSI LABS LIMITED.
- 66412-0204-
  66412-0204-2- 25 g in 1 BAG (66412-0204-2)

66412- VAMSI LABS LIMITED.
- 66412-0204-
  66412-0204-3- 50 g in 1 BAG (66412-0204-3)

66412- VAMSI LABS LIMITED.
- 66412-0204-
  66412-0204-4- 100 g in 1 BAG (66412-0204-4)

66412- VAMSI LABS LIMITED.
- 66412-0204-
  66412-0204-5- 200 g in 1 BAG (66412-0204-5)

66412- VAMSI LABS LIMITED.
- 66412-0204-
  66412-0204-6- 500 g in 1 DRUM (66412-0204-6)

66412- VAMSI LABS LIMITED.
- 66412-0204-
  66412-0204-7- 1000 g in 1 DRUM (66412-0204-7)

70748- Lupin Pharmaceuticals, Inc.
- 70748-261- formoterol fumarate
  70748-261-30- 30 POUCH in 1 CARTON (70748-261-30) / 1 VIAL in 1 POUCH / 2 mL in 1 VIAL

70748- Lupin Pharmaceuticals, Inc.
- 70748-261- formoterol fumarate
  - 70748-261-60- 60 POUCH in 1 CARTON (70748-261-60) / 1 VIAL in 1 POUCH / 2 mL in 1 VIAL

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Indications ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

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Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Classifications ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Canadian Brand Names ⬆ ⬇

Time/Action Profile ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

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