estetrol/drospirenone: ES-te-trol/droe-SPY-re-nown
ethinyl estradiol/desogestrel: ETH-in-il es-tra-DYE-ole/dess-oh-JESS-trel
ethinyl estradiol/drospirenone: ETH-in-il es-tra-DYE-ole/droe-SPY-re-nown
ethinyl estradiol/ethynodiol: ETH-in-il es-tra-DYE-ole/e-thye-noe-DYE-ole
ethinyl estradiol/levonorgestrel : ETH-in-il es-tra-DYE-ole/lee-voe-nor-JESS-trel
ethinyl estradiol/norethindrone : ETH-in-il es-tra-DYE-ole/nor-eth-IN-drone
ethinyl estradiol/norgestimate: ETH-in-il es-tra-DYE-ole/nor-JES-ti-mate
ethinyl estradiol/norgestrel : ETH-in-il es-tra-DYE-ole/nor-JESS-trel
ethinyl estradiol/desogestrel: ETH-in-il es-tra-DYE-ole/dess-oh-JESS-trel
ethinyl estradiol/norethindrone : ETH-in-il es-tra-DYE-ole/nor-eth-IN-drone
ethinyl estradiol/desogestrel: ETH-in-il es-tra-DYE-ole/dess-oh-JESS-trel
ethinyl estradiol/levonorgestrel: ETH-in-il ess-tra-DYE-ole/lee-voe-nor-JESS-trel
ethinyl estradiol/norethindrone : ETH-in-il es-tra-DYE-ole/nor-eth-IN-drone
ethinyl estradiol/norgestimate : ETH-in-il es-tra-DYE-ole/nor-JESS-ti-mate
estradiol valerate/dienogest: es-tra-DYE-ole VAL-er-ate/dye-EN-oh-jest
ethinyl estradiol/levonorgestrel: ETH-in-il ess-tra-DYE-ole/lee-voe-nor-JESS-trel
norethindrone: nor-eth-IN-drone
etonogestrel: e-toe-no-JESS-trel
levonorgestrel: LEE-voe-nor-JESS-trel
medroxyprogesterone: me-DROX-ee-proe-JESS-te-rone
levonorgestrel: LEE-voe-nor-JESS-trel
ethinyl estradiol/etonogestrel: ETH-in-il ess-tra-DYE-ole/e-toe-noe-JESS-trel
ethinyl estradiol/levonorgestrel: ETH-in-il ess-tra-DYE-ole/LEE-voe-nor-JESS-trel
ethinyl estradiol/norelgestromin: ETH-in-il ess-tra-DYE-ole/nor-el-JESS-troe-min
REMS
Monophasic Oral Contraceptives
Biphasic Oral Contraceptives
Triphasic Oral Contraceptives
Fourphasic Oral Contraceptives
Extended-cycle
Progressive Estrogen
Progestin-Only Contraceptives/Contraceptive Implant/Intrauterine Levonorgestrel/Medroxyprogesterone Injection
Emergency Contraceptive Pills
Vaginal Ring, Transdermal Patch
Anti-acne effect
Absorption: Ethinyl estradiol: rapidly absorbed; Norethindrone: 65% absorbed; Desogestrel and levonorgestrel: 100% absorbed; Dienogest: 91% absorbed. Others are well absorbed after oral administration. Slowly absorbed from implant, SUBQ or IM injection. Some absorption follows intrauterine implantation.
Distribution: Unknown.
Protein Binding: Ethinyl estradiol: 9798%; Drospirenone: 97%; Dienogest: 90%; Ulipristal: >94%.
Half-Life: Ethinyl estradiol: 620 hr; Levonorgestrel: 45 hr; Norethindrone: 514 hr; Desogestrel (metabolite): 38 ± 20 hr; Drospirenone: 30 hr; Norgestimate (metabolite): 1220 hr; Dienogest: 11 hr; others: unknown; Ulipristal: 32 hr.
(prevention of pregnancy)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | 1 mo | 1 mo | 1 mo‡ |
Implant | 1 mo | 1 mo | 5 yr |
Intrauterine system | 1 mo | 1 mo | 5 yr |
IM | 1 mo | 1 mo | 3 mo |
SUBQ | unknown | 1 wk | 3 mo |
‡Only during mo of taking contraceptive.
Contraindicated in:
Use Cautiously in:
CV: edema, hypertension, Raynauds phenomenon, THROMBOEMBOLISM, thrombophlebitis
Derm: melasma, rash
EENT: contact lens intolerance, optic neuritis, retinal thrombosis
Endo: hyperglycemia
F and E: Drosperinone-containing products only: hyperkalemia
GI: abdominal cramps, bloating, cholestatic jaundice, gallbladder disease, liver tumors, nausea, PANCREATITIS, vomiting
GU: Intrauterine levonorgestrel only:, amenorrhea, breakthrough bleeding, dysmenorrhea, spotting, uterine imbedment/uterine rupture
MS: Injectable medroxyprogesterone only: bone loss
Neuro: depression, headache
Misc: BREAST CANCER (ESPECIALLY WITH PROLONGED USE), HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA), weight change
Drug-drug:
Drug-Natural Products:
Monophasic Oral Contraceptives
Biphasic Oral Contraceptives
Triphasic Oral Contraceptives
Fourphasic Oral Contraceptives
Extended-Cycle Contraceptive
Progestin-Only Oral Contraceptives
Progressive Estrogen Oral Contraceptives
Emergency Contraceptive
Injectable Contraceptive
Intrauterine Contraceptive
Intrauterine
(Adults ): Insert one device into uterine cavity within 7 days of menses or immediately after 1st trimester abortion. Skyla should be removed or replaced after 3 yr. Kyleena, should be removed or replaced after 5 yr. Mirena and Liletta should be removed or replaced after 5 yr (for treatment of heavy menstrual bleeding) or 8 yr (contraception).Vaginal Ring Contraceptive
Transdermal Patch
Acne
Combination Estrogen/Progestin Oral Contraceptives
(Generic available)Extended-Cycle Contraceptive
Levonorgestrel
(Generic available)Etonorgestrel
Ulipristal
Medroxyprogesterone
(Generic available)Vaginal Ring Contraceptive
Transdermal Patch
Lab Test Considerations:
estetrol/drospirenone: Nextstellis,
ethinyl estradiol/desogestrel: Apri-28, Cyred EQ, Enskyce, Isibloom, Juleber, Kalliga, Reclipsen,
ethinyl estradiol/drospirenone: Beyaz, Jasmiel, Lo-Zumandimine, Loryna, Nikki, Ocella, Safyral, Syeda, Tydemy, Vestura, Yasmin, Yaz, Zumandimine,
ethinyl estradiol/ethynodiol: Kelnor 1/35, Kelnor 1/50, Zovia 1/35,
ethinyl estradiol/levonorgestrel : Afirmelle, Altavera, Aubra EQ, Aviane, Ayuna, Balcoltra, Chateal EQ, Falmina, Joyeaux, Kurvelo, Lessina, Levora-28, Lutera, Marlissa, Portia-28, Sronyx, Tyblume, Vienva,
ethinyl estradiol/norethindrone : Alyacen 1/35, Aurovela 1/20, Aurovela 1.5/30, Aurovela 24 Fe, Aurovela Fe 1/20, Aurovela Fe 1.5/30, Balziva, Blisovi 24 Fe, Blisovi Fe 1/20, Blisovi Fe 1.5/30, Briellyn, Charlotte 24 Fe, Cyonanz, Dasetta 1/35, Finzala, Fyavolv, Gemmily, Generess Fe, Hailey 1.5/30, Hailey 24 Fe, Hailey Fe 1/20, Hailey Fe 1.5/30, Jinteli, Junel 1/20, Junel 1.5/30, Junel Fe 1/20, Junel Fe 1.5/30, Junel Fe 24, Kaitlib Fe, Larin 1/20, Larin 1.5/30, Larin 24 Fe, Larin Fe 1/20, Larin Fe 1.5/30, Layolis Fe, Loestrin 1/20, Loestrin 1.5/30, Loestrin Fe 1/20, Loestrin Fe 1.5/30, Merzee, Mibelas 24 Fe, Microgestin 1/20, Microgestin 1.5/30, Microgestin 24 Fe, Microgestin Fe 1/20, Microgestin Fe 1.5/30, Minastrin 24 Fe, Necon 0.5/35, Nexesta Fe, Nortrel 0.5/35, Nortrel 1/35, Nylia 1/35, Philith, Tarina 24 Fe, Tarina Fe 1/20 EQ, Taysofy, Taytulla, Tilia Fe, Vyfemla, Wera, Wymzya Fe, Zenchent Fe,
ethinyl estradiol/norgestimate: Estarylla, Mili, Mono-Linyah, Nymyo, Previfem, Sprintec-28, VyLibra,
ethinyl estradiol/norgestrel : Cryselle-28, Elinest, Low-Ogestrel,
ethinyl estradiol/desogestrel: Azurette, Bekyree, Kariva, Mircette, Pimtrea, Simliya, Viorele, Volnea,
ethinyl estradiol/norethindrone : Lo Loestrin Fe,
ethinyl estradiol/desogestrel: Velivet,
ethinyl estradiol/levonorgestrel: Enpresse-28, Levonest, Trivora-28,
ethinyl estradiol/norethindrone : Alyacen 7/7/7, Aranelle, Dasetta 7/7/7, Leena, Nortrel 7/7/7, Nylia 7/7/7, Tri-Legest Fe,
ethinyl estradiol/norgestimate : Tri-Estarylla, Tri-Linyah, Tri-Lo-Estarylla, Tri-Lo-Marzia, Tri-Lo-Mili, Tri-Lo-Sprintec, Tri-Mili, Tri-Nymyo, Tri-Sprintec, Tri-VyLibra, Tri-VyLibra Lo,
estradiol valerate/dienogest: Natazia,
ethinyl estradiol/levonorgestrel: Amethia, Amethyst, Ashlyna, Camrese, Camrese Lo, Daysee, Dolishale, Iclevia, Introvale, Jaimiess, Jolessa, LoJaimiess, LoSeasonique, Quartette, Rivelsa, Seasonique, Setlakin, Simpesse,
norethindrone: Aygestin, Camila, Deblitane, Emzahh, Errin, Heather, Incassia, Jencycla, Lyleq, Nora-BE, Sharobel,
drospirenone: Slynd,
etonogestrel: Nexplanon,
levonorgestrel: Aftera, Athentia Next, Curae, EContra One-Step, Her Style, My Choice, My Way, New Day, Opcicon One-Step, Plan B One-Step, Take Action,
ulipristal: Ella,
medroxyprogesterone: Depo-Provera, Depo-subQ Provera 104,
levonorgestrel: Kyleena, Liletta, Mirena, Skyla,
ethinyl estradiol/etonogestrel: EluRyng, Enilloring, Haloette, NuvaRing,
ethinyl estradiol/levonorgestrel: Twirla,
ethinyl estradiol/norelgestromin: Xulane, Zafemy