A variety of neurologic problems can develop in critically ill pts. Most ICU pts develop delirium, which is characterized by acute changes in mental status, inattention, disorganized thinking, and an altered level of consciousness. Use of dexmedetomidine was associated with less ICU delirium than midazolam, one of the conventional sedatives. Less common but important neurologic complications include anoxic brain injury, stroke, and status epilepticus.