Most moderate hypercholesterolemia (<9.1 mmol/L [<350 mg/dL]) arises from an interaction of multiple genetic defects and environmental factors such as diet, age, and exercise. Plasma HDL and triglyceride levels are normal, and xanthomas are not present.
Treatment: Isolated Hypercholesterolemia Therapy for all of these disorders includes restriction of dietary cholesterol and HMG-CoA reductase inhibitors (statins). Cholesterol absorption inhibitors and bile acid sequestrants or nicotinic acid may also be required (Table 178-2). |
Section 13. Endocrinology and Metabolism