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Information

GH hypersecretion is primarily the result of pituitary somatotrope adenomas, mostly sporadic, but also in conjunction with MEN 1, Carney syndrome, McCune-Albright syndrome, and familial AIP mutations. Extrapituitary causes of acromegaly (ectopic growth hormone-releasing hormone [GHRH] production) are very rare.

Outline

Section 13. Endocrinology and Metabolism