Inhalational anesthetics depress the heart in a dose-dependent manner.
- In the past, anticholinergics were commonly used to prevent bradycardia and arrhythmias in children given halothane; however, this practice is no longer necessary with the newer ether anesthetics that infrequently cause arrhythmias.
- Sevoflurane maintains or increases heart rate during induction of anesthesia in most instances likely because of withdrawal of vagal tone. Desflurane and isoflurane tend to increase the heart rate.
- Cardiac output in young children is dependent on heart rate.
- Peripheral vascular resistance is very low in children as evidenced by the absence of a change in blood pressure when a caudal/epidural block is administered.