Drug-induced liver injury (DILI) is largely a diagnosis of exclusion and should always be considered when formulating the differential diagnosis of patients presenting with liver abnormalities.

1. DILI is a serious problem for the pharmaceutical industry because it is the most common reason for regulatory actions such as failure of approval, removal from market, or restrictions on indications for use.
2. Nonacetaminophen drug-induced idiosyncratic liver injury accounts for 11% to 13% of cases of ALF, and with a 20% rate of survival with supportive care, it has a poorer than average rate of spontaneous recovery.
3. In anesthesiology, perhaps the best-known potentially hepatotoxic drug is halothane.

The Liver: Surgery and Anesthesia

1. Assessment of Hepatic Function
2. Hepatobiliary Imaging
3. Liver Biopsy
4. Hepatic and Hepatobiliary Diseases
5. Acute Liver Failure
6. Acute Hepatitis
7. Alcoholic Hepatitis
8. Drug-Induced Liver Injury
9. Pregnancy-Related Liver Diseases
10. Cirrhosis and Portal Hypertension
11. Hemostasis
12. Cardiac Manifestations
13. Renal Dysfunction
14. Pulmonary Complications
15. Hepatic Encephalopathy (HE)
16. Ascites
17. Varices
18. Chronic Cholestatic Disease
19. Chronic Hepatocellular Disease
20. Hepatocellular Carcinoma (HCC)
21. Nonalcoholic Fatty Liver Disease
22. Preoperative Management
23. Intraoperative Management
24. Transjugular Intrahepatic Portosystemic Shunt Procedure
25. Hepatic Resection
26. Postoperative Liver Dysfunction