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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: peripheral edema, atrial fibrillation, tachycardia.

GI: abdominal pain, diarrhea, nausea, vomiting.

GU: serum creatinine.

Hemat: anemia, neutropenia, thrombocytopenia.

Neuro: fatigue, headache.

Resp: cough.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

Route/Dosage

IV therapy should only be used when patients are unable to take oral therapy.

Hematopoietic Stem Cell Transplant

Kidney Transplant

US Brand Names

Prevymis

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antivirals

Pharmacokinetics

Absorption: 35% absorbed following oral administration ( when cyclosporine given); IV administration results in complete bioavailability.

Distribution: Widely distributed.

Protein Binding: 99%.

Metabolism/Excretion: Primarily metabolized in liver via UGT1A1/UGT1A3; 93% excreted in feces (70% as unchanged drug); <2% excreted in urine.

Half-life: 12 hr.

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
IVrapidend of infusionunknown
POunknown0.75–2.25 hrunknown

Patient/Family Teaching

Pronunciation

le-TERM-oh-vir