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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: MI.

Derm: rash, STEVENS-JOHNSON SYNDROME.

Endo: glucose intolerance.

GI: diarrhea, nausea, vomiting, liver enzymes, abdominal pain.

GU: nephrolithiasis.

Hemat: neutropenia.

Metab: body fat, hyperlipidemia, hypertriglyceridemia.

Neuro: headache, fatigue, mood disorders.
Misc: (INCLUDING ANGIOEDEMA)HYPERSENSITIVITY REACTIONS , immune reconstitution syndrome.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

see Calculator

Hepatic Impairment

US Brand Names

Lexiva

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antiretrovirals

Pharmacologic Classification: protease inhibitors

Pharmacokinetics

Absorption: Fosamprenavir is a prodrug. Following oral administration, it is rapidly converted to amprenavir by the gut lining during absorption.

Distribution: Penetration into RBCs is concentration dependent.

Metabolism/Excretion: Primarily metabolized by the liver by the CYP3A4 isoenzyme. Minimal renal excretion.

Half-life: 7.7 hr.

Canadian Brand Names

Telzir

Time/Action Profile

(blood levels)

ROUTEONSETPEAKDURATION
POrapid1.5–4 hr12–24 hr

Patient/Family Teaching

Pronunciation

fos-am-PREN-a-veer