byoo-PI-vi-kane
REMS
Implant
Absorption: Systemic absorption follows epidural administration, but amount absorbed depends on dose.
Distribution: If systemic absorption occurs, this agent is widely distributed and crosses the placenta.
Half-Life: 1.5—5 hr (after epidural use); 19 hr (implant).
(analgesia)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| Epidural | 10–30 min | Unknown | 2–8 hr‡ |
| Implant | Unknown | Unknown | Unknown |
‡Duration of anesthetic block.
Contraindicated in:
Use Cautiously in:
CV: arrhythmias, bradycardia, CARDIOVASCULAR COLLAPSE, hypotension
Derm: pruritus
EENT: blurred vision, tinnitus
F and E: metabolic acidosis
Hemat: methemoglobinemia
Local: incision site swelling/pain (implant)
Neuro: anxiety, circumoral tingling/numbness, dizziness, dysgeusia, headache, irritability, SEIZURES, tremor
Misc: fever, allergic reactions
Drug-drug:
Caudal block
(Adults and Children >12 yr): 15–30 mL of 0.25% or 0.5% solution. A test dose of 2–3 mL of 0.5% with epinephrine solution is recommended prior to caudal blocks.Peripheral nerve block
(Adults and Children >12 yr): 5 mL of 0.25% or 0.5% solution (maximum dose = 400 mg).Sympathetic nerve block
(Adults and Children >12 yr): 20–50 mL of 0.25% solution.Dental block
(Adults and Children >12 yr): 1.8–3.6 mL per site of 0.5% with epinephrine solution.Local infiltration
(Adults and Children >12 yr): 0.25% solution infiltrated locally (maximum dose = 175 mg).Implant
(Adults ): 300 mg (three 100–mg implants) as single dose.NDC Code