Contraindicated in:
Use Cautiously in:
GI: constipation, ↑ liver enzymes, abdominal distention, abdominal pain, fecal impaction, flatulence, GI OBSTRUCTION/PERFORATION, nausea, PANCREATITIS, sphincter of Oddi spasm, vomiting.
Neuro: dizziness, fatigue.
Drug-Drug:
Hepatic Impairment
Renal Impairment
Therapeutic Classification: anti irritable bowel syndrome agents, mu-opioid receptor agonists
Absorption: Some systemic absorption follows oral administration (bioavailaibility unknown).
Distribution: Unknown.
Metabolism/Excretion: Mostly metabolized by the liver; <1% excreted in urine.
Half-life: 3.76 hr.
NDC Code*