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Indications ⬇

REMS

Implant:

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: arrhythmias, bradycardia, CARDIOVASCULAR COLLAPSE, hypotension.

Derm: pruritus.

EENT: blurred vision, tinnitus.

F and E: metabolic acidosis.

GI: nausea, vomiting.

GU: urinary retention.

Hemat: methemoglobinemia.

Local: incision site swelling/pain (implant).

Neuro: anxiety, circumoral tingling/numbness, dizziness, dysgeusia, headache, irritability, SEIZURES, tremor.

Misc: fever, allergic reactions.

Interactions ⬆ ⬇

Drug-Drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Solutions containing preservatives should not be used for caudal or epidural blocks.

US Brand Names ⬆ ⬇

Marcaine, Sensorcaine, Xaracoll

Action ⬆ ⬇

Therapeutic Effects:

Classifications ⬆ ⬇

Therapeutic Classification: epidural local anesthetics, anesthetics (topical/local)

Pharmacokinetics ⬆ ⬇

Absorption: Systemic absorption follows epidural administration, but amount absorbed depends on dose.

Distribution: If systemic absorption occurs, this agent is widely distributed and crosses the placenta.

Metabolism/Excretion: Small amounts that may reach systemic circulation are mostly metabolized by the liver; 6% excreted unchanged in the urine.

Half-life: 1.5—5 hr (after epidural use); 19 hr (implant).

Time/Action Profile ⬆ ⬇

(analgesia)

ROUTEONSETPEAKDURATION
Epidural10–30 minUnknown2–8 hr†
ImplantUnknownUnknownUnknown

†Duration of anesthetic block.

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

byoo-PI-vi-kane audio

Code ⬆

NDC Code*