Paxil, Paxil CR, Pexeva:
Paxil, Pexeva:
Paxil, Paxil CR:
Paxil:
Paxil CR:
Paroxetine mesylate (7.5–mg capsule):
Contraindicated in:
Use Cautiously in:
CV: chest pain, edema, hypertension, palpitations, postural hypotension, tachycardia, vasodilation.
Derm: sweating, photosensitivity, pruritus, rash, STEVENS-JOHNSON SYNDROME (SJS).
EENT: blurred vision, pharyngitis, rhinitis.
Endo: SIADH.
F and E: hyponatremia.
GI: constipation, diarrhea, dry mouth, nausea, abdominal pain, dyspepsia, flatulence, taste disturbances, vomiting.
GU: ↓ libido, delayed/absent orgasm, ejaculatory delay/failure, erectile dysfunction, genital disorders, infertility, urinary disorders, urinary frequency.
Hemat: BLEEDING.
Metab: ↓/↑ appetite, weight gain/loss.
MS: back pain, bone fracture, myalgia, myopathy.
Neuro: anxiety, dizziness, drowsiness, headache, insomnia, weakness, agitation, amnesia, confusion, depression, emotional lability, hangover, impaired concentration, malaise, NEUROLEPTIC MALIGNANT SYNDROME, paresthesia, SUICIDAL THOUGHTS, syncope, tremor.
Resp: cough, yawning.
Misc: chills, fever, SEROTONIN SYNDROME.
Drug-Drug:
Drug-Natural Products:
(Generic available)
Depression
Obsessive Compulsive Disorder
Panic Disorder
Social Anxiety Disorder
Generalized Anxiety Disorder
Post-Traumatic Stress Disorder
Premenstrual Dysphoric Disorder
Menopausal Vasomotor Symptoms
Hepatic Impairment
Renal Impairment
Therapeutic Classification: antianxiety agents, antidepressants
Pharmacologic Classification: selective serotonin reuptake inhibitors ssris
Absorption: Completely absorbed following oral administration. Controlled-release tablets are enteric-coated and control medication release over 4–5 hr.
Distribution: Widely distributed throughout body fluids and tissues, including the CNS; cross the placenta and enter breast milk.
Protein Binding: 95%.
Metabolism/Excretion: Highly metabolized by the liver, primarily by the CYP2D6 isoenzyme; the CYP2D6 isoenzyme exhibits genetic polymorphism; 7% of population may be poor metabolizers and may have significantly ↑ paroxetine concentrations and an ↑ risk of adverse effects. 2% excreted unchanged in urine.
Half-life: 21 hr.
NDC Code*