Information ⬇
- Acute relapses that produce functional impairment may be treated with a short course of IV methylprednisolone (500-1000 mg IV q A.M. × 3-5 days) followed often by oral prednisone (60 mg q A.M. × 4, 40 mg q A.M. × 4, 20 mg q A.M. × 3). This regimen modestly reduces the severity and shortens the duration of attacks.
- Plasma exchange (seven exchanges: 40-60 mL/kg, every other day for 14 days) may benefit pts with fulminant attacks of demyelination (not only MS) that are unresponsive to glucocorticoids; cost is high and conclusive evidence of efficacy is lacking.
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