Drugs (including glucocorticoids and lipid-lowering agents) and toxins (e.g., alcohol) are associated with myopathies (Table 195-2). In most cases, weakness is symmetric and involves proximal limb girdle muscles; myalgia and cramps may also occur. An elevated CK is often found. Diagnosis often depends on resolution of signs and symptoms with removal of offending agent.
For a more detailed discussion, see Amato AA, Brown RH Jr.: Muscular Dystrophies and Other Muscle Diseases, Chap. 462e; Dalakas MC: Polymyositis, Dermatomyositis, and Inclusion Body Myositis, Chap. 388, p. 2194, in HPIM-19. |