Neurologic manifestations consist of persistent headache with or without stiff neck and hydrocephalus; cranial neuropathies; radiculopathies; and/or cognitive or personality changes (Table 192-1). The diagnosis is usually made when clinical presentation leads the physician to examine CSF for signs of inflammation; on occasion the diagnosis is made when a neuroimaging study shows contrast enhancement of the meninges.
Two clinical forms of chronic meningitis exist. In the first, symptoms are chronic and persistent, whereas in the second there are recurrent, discrete episodes with complete resolution of meningeal inflammation between episodes without specific therapy. In the latter group, likely etiologies are herpes simplex virus type 2, chemical meningitis due to leakage from a tumor, a primary inflammatory condition, or drug hypersensitivity.
Approach to the Patient: Chronic Meningitis Once chronic meningitis is confirmed by CSF examination, effort is focused on identifying the cause (Tables 192-2 and 192-3) by (1) further analysis of the CSF, (2) diagnosis of an underlying systemic infection or noninfectious inflammatory condition, or (3) examination of meningeal biopsy tissue. Proper analysis of the CSF is essential; if the possibility of raised intracranial pressure (ICP) exists, a brain imaging study should be performed before LP. In pts with communicating hydrocephalus caused by impaired resorption of CSF, LP is safe and may lead to temporary improvement. However, if ICP is elevated because of a mass lesion, brain swelling, or a block in ventricular CSF outflow (obstructive hydrocephalus), then LP carries the potential risk of brain herniation. Obstructive hydrocephalus usually requires direct ventricular drainage of CSF. Contrast-enhanced MRI or CT studies of the brain and spinal cord can identify meningeal enhancement, parameningeal infections (including brain abscess), encasement of the spinal cord (malignancy or inflammation and infection), or nodular deposits on the meninges or nerve roots (malignancy or sarcoidosis). Imaging studies are also useful to localize areas of meningeal disease prior to meningeal biopsy. Cerebral angiography may identify arteritis. A meningeal biopsy should be considered in pts who are disabled, who need chronic ventricular decompression, or whose illness is progressing rapidly. The diagnostic yield of meningeal biopsy can be increased by targeting regions that enhance with contrast on MRI or CT; in one series, biopsies most often identified sarcoid (31%) or metastatic adenocarcinoma (25%). Tuberculosis is the most common condition identified in many reports outside of the United States. In approximately one-third of cases, the diagnosis is not established despite careful evaluation. A number of the organisms that cause chronic meningitis may take weeks to be identified by culture. It is reasonable to wait until cultures are finalized if symptoms are mild and not progressive. However, in many cases progressive neurologic deterioration occurs, and rapid treatment is required. Empirical therapy in the United States consists of antimycobacterial agents, amphotericin for fungal infection, or glucocorticoids for noninfectious inflammatory causes (most common). It is important to direct empirical therapy of lymphocytic meningitis at tuberculosis, particularly if the condition is associated with hypoglycorrhachia and sixth and other cranial nerve palsies, since untreated disease can be fatal within weeks. Carcinomatous or lymphomatous meningitis may be difficult to diagnose initially, but the diagnosis becomes evident with time. Important causes of chronic meningitis in HIV pts include infection with Toxoplasma (usually presents as intracranial abscesses), Cryptococcus, Nocardia, Candida, or other fungi; syphilis; and lymphoma. |
For a more detailed discussion, see Koroshetz WJ, Nath A: Chronic and Recurrent Meningitis, Chap. 165, p. 906, in HPIM-19. |