Contraindicated in:
Use Cautiously in:
CV: QT interval prolongation, TORSADES DE POINTES.
Derm: ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), pruritus, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS.
GI: CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), abdominal pain/discomfort, abnormal taste, diarrhea, dyspepsia, HEPATOTOXICITY, nausea.
Neuro: headache.
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA).
Drug-Drug:
(Generic available)
Renal Impairment
Spectrum:
Therapeutic Classification: agents for atypical mycobacterium, anti-infectives, antiulcer agents
Pharmacologic Classification: macrolides
Absorption: Rapidly absorbed (50%) after oral administration.
Distribution: Widely distributed; tissue levels may exceed those in serum.
Protein Binding: 6570%.
Metabolism/Excretion: 1015% converted by the liver to 14-hydroxyclarithromycin, which has anti-infective activity; 2030% excreted unchanged in urine. Metabolized by and also inhibits the CYP3A enzyme system.
Half-life: Dose-dependent and prolonged with renal dysfunction 250-mg dose: 34 hr; 500-mg dose: 57 hr.
NDC Code*