KLOE-za-peen 
Contraindicated in:
Use Cautiously in:
CV: hypotension, tachycardia, QT interval prolongation, bradycardia, CARDIAC ARREST, DEEP VEIN THROMBOSIS, HF, hypertension, MITRAL VALVE INCOMPETENCE, MYOCARDITIS, syncope, TORSADES DE POINTES, VENTRICULAR ARRHYTHMIAS.
Derm: rash, sweating.
EENT: visual disturbances.
Endo: hyperglycemia.
GI: constipation, ↑ salivation, abdominal discomfort, dry mouth, GI ISCHEMIA/INFARCTION/NECROSIS, GI OBSTRUCTION, GI PERFORATION, HEPATOTOXICITY, nausea, ulceration, vomiting.
GU: nocturnal enuresis.
Hemat: AGRANULOCYTOSIS, LEUKOPENIA.
Metab: hyperlipidemia, weight gain.
Neuro: dizziness, sedation, extrapyramidal reactions, NEUROLEPTIC MALIGNANT SYNDROME, SEIZURES.
Resp: PULMONARY EMBOLISM.
Misc: fever.
Drug-Drug:
Drug-Natural Products:
(Generic available)
Clozaril, FazaClo, Versacloz
Absorption: Well absorbed after oral administration.
Distribution: Rapid and extensive distribution; crosses blood-brain barrier.
Protein Binding: 95%.
Metabolism/Excretion: Mostly metabolized through the liver by the CYP1A2, CYP2D6, and CYP3A4 isoenzymes; (the CYP2D6 enzyme system exhibits genetic polymorphism; 7% of population may be poor metabolizers and may have significantly ↑ clozapine concentrations and an ↑ risk of adverse effects).
Half-life: 8–12 hr.
NDC Code*