Information ⬇
- Toxic granulations: dark cytoplasmic granules; bacterial infection.
- Döhle bodies: 1- to 2-µm blue, oval cytoplasmic inclusions; bacterial infection, Chédiak-Higashi anomaly.
- Auer rods: eosinophilic, rodlike cytoplasmic inclusions; acute myeloid leukemia (some cases).
- Hypersegmentation: neutrophil nuclei contain more than the usual 2-4 lobes; usually >5% have ≥5 lobes or a single cell with 7 lobes is adequate to make the diagnosis; folate or B12 deficiency, drug effects.
- Hyposegmentation: neutrophil nuclei contain fewer lobes than normal, either one or two: Pelger-Hüet anomaly, pseudo-Pelger-Hüet or acquired Pelger-Hüet anomaly in acute leukemia.
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