Finasteride and dutasteride have been shown to reduce the incidence of prostate cancer by 25%, but no effect on overall survival has been seen with limited follow-up. In addition, the cancers that do occur appear to be shifted to higher Gleason grades, but the clinical course of disease does not seem to be altered.
For a more detailed discussion, see Scher HI, Eastham JA: Benign and Malignant Diseases of the Prostate, Chap. 115, p. 579, in HPIM-19. |
Section 6. Hematology and Oncology