1. Antifibrinolytic agents have been used to prevent and treat surgical blood loss.
2. There are two types, the lysine analogs, epsilon-aminocaproic acid (EACA) and tranexamic acid (TXA), and a serine protease inhibitor, aprotinin.
   1. Aprotinin reduces perioperative blood loss, transfusions, and the need for reoperations.
   2. There is also an abundance of evidence reporting the negative association of aprotinin with renal failure and mortality.

Hemostasis and Transfusion Medicine

1. Hemostasis and Coagulation
2. Fibrinolysis
3. Laboratory Evaluation of Hemostasis
4. Laboratory Evaluation of Primary Hemostasis
5. Laboratory Evaluation of Secondary Hemostasis and Coagulation
6. Diagnosis of Thromboembolic Disorders
7. Monitoring Anticoagulation Therapeutic Agents
8. Blood Component Production
9. Blood Products and Transfusion Thresholds
10. Physiologic Compensation for Anemia
11. Platelets
12. Fresh Frozen Plasma
13. Cryoprecipitate
14. The Risks of Blood Product Administration
15. Blood Conservation Strategies
16. Disorders of Hemostasis: Diagnosis and Treatment
17. Anticoagulation and Pharmacologic Therapy
18. Prothrombin Complex Concentrates
19. Desmopressin
20. Antifibrinolytic Therapy