The risk for deep vein thrombosis (DVT) is increased by intercurrent factors such as physical inactivity or immobilization, malignancy, oral contraceptives, estrogen therapy, and pregnancy.

1. Congenital Risk Factors for Thrombosis
   1. Congenital problems are mostly categorized as deficiencies in antithrombotic pathways or hypercoagulable clotting factors.
   2. Several congenital factors involve the protein C-ase complex and its function. Protein C itself is functionally deficient in up to 0.5% of the population, with autosomal dominant inheritance. This leads to overactive factor VIII and factor V cofactors in their respective intrinsic tenase and prothrombinase complexes.
2. Acquired Risk Factors for Thrombosis (Table 16-2: Acquired Risk Factors for Thrombosis)

Hemostasis and Transfusion Medicine

1. Hemostasis and Coagulation
2. Fibrinolysis
3. Laboratory Evaluation of Hemostasis
4. Laboratory Evaluation of Primary Hemostasis
5. Laboratory Evaluation of Secondary Hemostasis and Coagulation
6. Diagnosis of Thromboembolic Disorders
7. Monitoring Anticoagulation Therapeutic Agents
8. Blood Component Production
9. Blood Products and Transfusion Thresholds
10. Physiologic Compensation for Anemia
11. Platelets
12. Fresh Frozen Plasma
13. Cryoprecipitate
14. The Risks of Blood Product Administration
15. Blood Conservation Strategies
16. Disorders of Hemostasis: Diagnosis and Treatment
17. Anticoagulation and Pharmacologic Therapy
18. Prothrombin Complex Concentrates
19. Desmopressin
20. Antifibrinolytic Therapy