Contraindicated in:
Use Cautiously in:
Exercise Extreme Caution in:
CV: hypertension, QT interval prolongation, HF, TORSADES DE POINTES.
Derm: acne, photosensitivity reaction, rash, impaired wound healing, pruritus, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS.
Endo: hypothyroidism.
F and E: hypocalcemia.
GI: ↓ appetite, abdominal pain, diarrhea, nausea, GI PERFORATION, dyspepsia, vomiting.
GU: proteinuria, renal failure.
Hemat: BLEEDING.
Neuro: fatigue, headache, depression, insomnia, REVERSIBLE POSTERIOR LEUKOENCEPHALOPATHY SYNDROME (RPLS), STROKE.
Resp: INTERSTITIAL LUNG DISEASE (ILD), upper respiratory tract infection.
Drug-Drug:
Drug-Natural Products:
Renal Impairment
Absorption: Well absorbed following oral administration.
Distribution: Extensively distributed to tissues.
Metabolism/Excretion: Mostly metabolized by the liver; 44% excreted in feces, 25% in urine.
Half-life: 19 days.
NDC Code*