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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: reversible alopecia.

GI: liver enzymes ( in hydatid disease), abdominal pain (hydatid disease only), nausea/vomiting ( in neurocysticercosis).

Hemat: AGRANULOCYTOSIS, GRANULOCYTOPENIA, PANCYTOPENIA.

Neuro: headache ( in neurocysticercosis), intracranial pressure ( in neurocysticercosis), dizziness/vertigo, meningeal signs (in neurocysticercosis only).
Misc: fever (hydatid disease only).

Interactions

Drug-Drug:

Drug-Food:

Availability

(Generic available)

Route/Dosage

Hydatid Disease

Neurocysticercosis

US Brand Names

Albenza

Action

Therapeutic Effects:

Spectrum:

Classifications

Therapeutic Classification:

Pharmacokinetics

Absorption: Poorly absorbed following oral administration because of extensive first-pass hepatic metabolism, resulting in rapid conversion to albendazole sulfoxide, the active metabolite.

Distribution: Widely distributed.

Protein Binding: 70% bound to plasma proteins.

Metabolism/Excretion: After conversion to the sulfoxide metabolite, further hepatic metabolism to inactive compounds occurs. <1% excreted in urine; excretion is primarily via bile.

Half-life: Albendazole sulfoxide: 8–12 hr.

Time/Action Profile

(blood levels of albendazole sulfoxide)

ROUTEONSETPEAKDURATION
POunknown2–5 hrunknown

Patient/Family Teaching

Pronunciation

al-BEN-da-zole