Altered colonic motility due to neurologic dysfunction (diabetes mellitus, spinal cord injury, multiple sclerosis, Chagas' disease, Hirschsprung's disease, chronic idiopathic intestinal pseudoobstruction, idiopathic megacolon), scleroderma, drugs (esp. anticholinergic agents, opiates, aluminum- or calcium-based antacids, calcium channel blockers, iron supplements, sucralfate), hypothyroidism, Cushing's syndrome, hypokalemia, hypercalcemia, dehydration, mechanical causes (colorectal tumors, diverticulitis, volvulus, hernias, intussusception), and anorectal pain (from fissures, hemorrhoids, abscesses, or proctitis) leading to retention, constipation, and fecal impaction.
Treatment: Constipation A management approach is shown in Fig. 40-3. In the absence of identifiable cause, constipation may improve with reassurance, exercise, increased dietary fiber, bulking agents (e.g., psyllium), and increased fluid intake. Specific therapies include removal of bowel obstruction (fecalith, tumor), discontinuance of nonessential hypomotility agents (esp. aluminum or calcium-containing antacids, opiates), or substitution of magnesium-based antacids for aluminum-based antacids. For symptomatic relief, magnesium-containing agents or other cathartics are occasionally needed. With severe hypo- or dysmotility or in the presence of opiates, osmotically active agents (e.g., oral lactulose, intestinal polyethylene glycol-containing lavage solutions) and oral or rectal emollient laxatives (e.g., docusate salts) and mineral oil are most effective. |
For a more detailed discussion, see Camilleri M, Murray JA: Diarrhea and Constipation, Chap. 55, p. 264; and Binder HJ: Disorders of Absorption, Chap. 349, p. 1932, in HPIM-19. |
Section 3. Common Patient Presentations