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Cardiogenic pulmonary edema results from cardiac abnormalities that cause increased pulmonary venous pressure leading to interstitial edema; with greater pressures, alveolar edema and pleural effusions develop. Symptoms include exertional dyspnea and orthopnea. Physical examination can reveal S3 gallop, elevated jugular venous pressure, and peripheral edema. Chest radiographs show prominent vascular markings in the upper lung zones. CXRs demonstrate perihilar alveolar opacities progressing to diffuse parenchymal abnormalities as pulmonary edema worsens.

Noncardiogenic pulmonary edema results from damage to the pulmonary capillary lining. Hypoxemia relates to intrapulmonary shunt; decreased pulmonary compliance is observed. Clinical impact can range from mild dyspnea to severe respiratory failure. Normal intracardiac pressures are typically observed. Etiologies may be direct injury (e.g., aspiration, smoke inhalation, pneumonia, oxygen toxicity, or chest trauma), indirect injury (e.g., sepsis, pancreatitis, and transfusion-related acute lung injury), or pulmonary vascular (e.g., high altitude and neurogenic pulmonary edema). Chest radiograph typically shows normal heart size and diffuse alveolar infiltrates; pleural effusions are atypical. Hypoxemia in noncardiogenic pulmonary edema often requires treatment with high concentrations of oxygen.

For a more detailed discussion, see Schwartzstein RM: Dyspnea, Chap. 47e, in HPIM-19.

Outline

Section 3. Common Patient Presentations