The differential diagnosis is often between syncope and a generalized seizure. Syncope is more likely if the event was provoked by acute pain or emotion or occurred immediately after arising from a lying or sitting position; seizures are typically not related to posture. Pts with syncope often describe a stereotyped transition from consciousness to unconsciousness that develops over a few seconds. Seizures either occur very abruptly without a transition or are preceded by premonitory symptoms such as an epigastric rising sensation, perception of odd odors, or racing thoughts. Pallor is seen during syncope; cyanosis is usually seen during a seizure. The duration of unconsciousness is usually very brief (i.e., seconds) in syncope and more prolonged (i.e., >5 min) in a seizure. Injury from falling and incontinence are common in seizure, rare in syncope. Whereas tonic-clonic movements are the hallmark of a generalized seizure, myoclonic and other movements also occur in up to 90% of syncopal episodes and eyewitnesses will often have a difficult time distinguishing between the two etiologies.
Section 3. Common Patient Presentations