Pts with restless legs syndrome (RLS) complain of creeping dysesthesias deep within the calves or feet associated with an irresistible urge to move the affected limbs; symptoms are typically worse at night. Iron deficiency and renal failure can cause secondary RLS. One-third of pts have multiple affected family members. Treatment is with dopaminergic drugs (pramipexole 0.25-0.5 mg daily at 7 pm or ropinirole 0.5-4.0 mg daily at 7 pm). Periodic limb movements of sleep (PLMS) consist of stereotyped extensions of the great toe and dorsiflexion of the foot recurring every 20-40 s during non-REM sleep. Treatment options include dopaminergic medications.