Most GBS infections in adults are related to pregnancy and parturition. Other GBS infections are seen in the elderly, especially pts with underlying conditions such as diabetes mellitus or cancer.

• Cellulitis and soft tissue infection, UTI, pneumonia, endocarditis, and septic arthritis are most common.
• Penicillin (12 mU/d for localized infections and 18-24 mU/d for endocarditis or meningitis, in divided doses) is recommended. Vancomycin is an acceptable alternative for penicillin-allergic pts.
• Relapse or recurrent invasive infection occurs in ~4% of cases.