In children, adenovirus causes acute upper and lower respiratory tract infections and outbreaks of pharyngoconjunctival fever (a syndrome of fever, bilateral conjunctivitis, sore throat, and cervical adenopathy typically due to types 3 and 7).

• In adults (particularly military recruits), adenovirus types 4 and 7 cause an acute respiratory disease consisting of a prominent sore throat, fever on the second or third day of illness, cough, coryza, and regional adenopathy. Pharyngeal edema and tonsillar hypertrophy with little or no exudate may be seen.
• In addition to respiratory disease, adenovirus can cause diarrheal illness, hemorrhagic cystitis, and epidemic keratoconjunctivitis. In pts who have received a solid-organ transplant, adenovirus can affect the transplanted organ and disseminate to other organs.