The clinical manifestations of cryptococcosis reflect the site of fungal infection, usually involving the CNS and/or the lungs.

• CNS involvement most commonly presents as chronic meningoencephalitis, with headache, fever, lethargy, sensory and memory deficits, cranial nerve paresis, visual deficits, and meningismus (absent in some cases) lasting for weeks.
• Pulmonary cryptococcosis is generally asymptomatic but can present as cough, increased sputum production, and chest pain. Cryptococcomas are granulomatous pulmonary masses associated with C. gattii infections.
• Skin lesions are common in pts with disseminated cryptococcosis and can be highly variable, including papules, plaques, purpura, vesicles, tumor-like lesions, and rashes.