Cytomegalic inclusion disease occurs in ~5% of infected fetuses in the setting of primary maternal CMV infection in pregnancy.

• Petechiae, hepatosplenomegaly, and jaundice are present in 60-80% of cases; microcephaly with or without cerebral calcifications, intrauterine growth retardation, prematurity, and chorioretinitis are less common.
• Laboratory findings include elevated values in LFTs, thrombocytopenia, conjugated hyperbilirubinemia, hemolysis, and increased CSF protein levels.
• The mortality rate is 20-30% among infants with severe disease; survivors have intellectual or hearing difficulties.