80-90% of women and >50% of men with C. trachomatis genital infections lack symptoms; other pts have very mild symptoms.

• Urethritis, epididymitis, cervicitis, salpingitis, PID, and proctitis are all discussed above.
• Reactive arthritis (conjunctivitis, urethritis or cervicitis, arthritis, and mucocutaneous lesions) occurs in 1-2% of NGU cases, many of which are due to C. trachomatis. More than 80% of pts have the HLA-B27 phenotype.
• LGV is an invasive, systemic STI that—in heterosexual individuals—presents most commonly as painful inguinal lymphadenopathy beginning 2-6 weeks after presumed exposure. Progressive periadenitis results in fluctuant, suppurative nodes with development of multiple draining fistulas. Spontaneous resolution occurs after several months. See Table 83-1 for additional clinical details.