Signs and symptoms last 2-6 weeks and include high fevers, profound fatigue and malaise, myalgias, headache, and splenomegaly. In contrast to EBV infection, exudative pharyngitis and cervical lymphadenopathy are rare in CMV infection.

• Laboratory findings include relative lymphocytosis with >10% atypical lymphocytes, transaminitis, and immunologic abnormalities (e.g., the presence of cryoglobulins, rheumatoid factor, or cold agglutinins).
• The incubation period ranges from 20 to 60 days.
• Recovery is generally complete, but postviral asthenia can persist for months.