Of pts with CSD, 85-90% have typical disease consisting of a localized lesion (papule, vesicle, or nodule) at the site of inoculation with subsequent painful regional lymphadenopathy ≥1-3 weeks after cat contact.

• Axillary and epitrochlear nodes are most commonly involved and suppurate in 10-15% of cases.
• Low-grade fever, malaise, and anorexia develop in ~50% of pts.
• Atypical disease involves extranodal manifestations (e.g., fever of unknown origin, ophthalmologic manifestations, neurologic involvement, osteomyelitis) and occurs in 10-15% of pts.
• In immunocompetent pts, the disease resolves spontaneously without treatment, although its resolution takes weeks or months.