(See Also Table 226-11, pp. 1251-1253, in HPIM-19)

Primary prophylaxis is clearly indicated for P. jiroveci pneumonia (especially when CD4+ T cell counts fall to <200 cells/µL), for M. avium complex infections in pts with CD4+ T cell counts <50 cells/µL, and for M. tuberculosis infections in pts with a positive PPD or anergy if at high risk of TB. Vaccination with the influenza and pneumococcal polysaccharide vaccines is generally recommended for all pts and may need to be repeated in pts with CD4+ T cell counts <200/µL when their counts increase to >200/µL. Secondary prophylaxis, when available, is indicated for virtually every infection experienced by HIV-infected pts until they have significant immunologic recovery.