As of January 1, 2014, an estimated 1,194,039 cumulative cases of AIDS had been diagnosed in the United States; approximately 660,000 people with an AIDS diagnosis have died. However, the death rate from AIDS has decreased substantially over the past two decades, primarily due to the increased use of effective antiretroviral drugs. Currently, an estimated 1.2 million people are living with HIV infection in the United States; approximately 13% of these individuals are unaware that they are infected. An estimated 50,000 individuals are newly infected each year in the United States; this figure has remained stable for at least 15 years. Among adults and adolescents newly diagnosed with HIV infection in 2013, ~80% were men and ~20% were women. Of new HIV/AIDS diagnoses among men, ~81% were due to male-to-male sexual contact, ~10% to heterosexual contact, and ~5% to injection drug use. Among women, ~87% were due to heterosexual contact and ~12% to injection drug use. HIV infection/AIDS is a global pandemic, especially in developing countries. At the end of 2014, the estimated number of cases of HIV infection worldwide was ~36.9 million, more than two-thirds of which were in sub-Saharan Africa; ~47% of cases were in women and 2.6 million were in children. In 2014, there were 2 million new HIV infections worldwide and 1.2 million deaths.